# Block Searcher Results

Go to hits

### Introduction

    BLKPROB Version  4/11/99.1
    Database=../data-blplus/blocks.dat
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    Here are your search results. The database searched was Blocks+ (19 Mar 99)
    which includes: BLOCKS 11.0 consisting of 4034 blocks representing 994 groups
    documented in PROSITE 15, plus 2277 blocks from 352 groups documented in
    PRINTS 22.0 but not represented in BLOCKS, plus 1083 blocks from 254 groups
    documented in PFAM 3.4 but not represented in BLOCKS or PRINTS, plus
    1035 blocks from 268 groups documented in PRODOM 36 but not represented in
    BLOCKS, PRINTS or PFAM, plus 480 blocks from 127 groups documented in DOMO 2.0
    but not represented in BLOCKS, PRINTS, PFAM or PRODOM for a total of 8909
    blocks from 1995 groups.  Get more information at http://blocks.fhcrc.org.
    If you found the Blocks Searcher useful, please cite:
       S Henikoff & JG Henikoff, "Protein family classification
       based on searching a database of blocks", Genomics 19:97-107 (1994).
    ==============================================================================
    Each hit consists of one or more blocks from a protein group found
    in the query sequence. One set of the highest-scoring blocks that are in the
    correct order and separated by distances comparable to the Blocks database is
    selected for analysis. If this set includes multiple blocks the probability
    that the lower scoring blocks support the highest scoring block is reported.
    Maps of the database blocks and query sequence are shown:
    AAA represents a block roughly in proportion to its width.
      : represents the minimum distance between blocks in the database.
      . represents the maximum distance between blocks in the database.
    < > indicate the sequence has been truncated to fit the page.
    The query map is aligned on the highest scoring block. Multiple block hits
    that are consistent with the highest scoring block are separated by colons.
    Block hits that are not consistent are mapped below. The alignment of the
    query sequence with the sequence closest to it in the BLOCKS database is
    shown. The distance between detected blocks is listed as (min, max): for the
    database entry followed by the distance in the query. Upper case in the query
    indicates at least one occurrence of the residue in that column of the block.

    =============================================================================
    Note: For searches using DNA queries, "Location" refers to the position
    in the query in base pairs from 5' to 3' on the + strand, whereas the map and
    alignment show the translated position in amino acid residues.
    =============================================================================

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###

    Hits
    Query=7UP1_DROME|P16375    STEROID RECEPTOR SEVEN-UP TYPE 1 | PS00031
    Size=543 Amino Acids
    Blocks Searched=8909
    Alignments Done=5067002
    Cutoff Expected Value=  2
    ==============================================================================
                                                               Anchor   Combined
    Family                                     Strand Blocks   E-value  E-value
    BL00031 Nuclear hormones receptors DNA-bind   1   2 of 2   9.1e-27  4.9e-52
    PR00545 RETINOIC ACID RECEPTOR SIGNATURE      1   6 of 8   1.1e-09  4.3e-22
    PR00546 THYROID HORMONE RECEPTOR SIGNATURE    1   2 of 9        11     0.56
    PR00307 ADENOVIRUS FIBRE PROTEIN SIGNATURE    1   1 of 7       1.2      1.1
    PR00678 PI3 KINASE P85 REGULATORY SUBUNIT S   1   1 of 10      1.6      1.6
    BL01114 GPR1/FUN34/yaaH family proteins.      1   1 of 4       1.7      1.6

    ==============================================================================
    >BL00031 2/2 blocks: Nuclear hormones receptors DNA-binding region proteins.
    Block    Frame    Location (aa)      Block E-value
    BL00031A    0        200-232            9.1e-27
    BL00031B    0        234-265            3.6e-24
    Other reported alignments:

                             |---   31 amino acids---|
         BL00031 AAAAAAAAAAAAAAAAAAAAAAAAAA........BBBBBBBBBBBBBBBBBBBBBBBBBB
      7UP1_DROME AAAAAAAAAAAAAAAAAAAAAAAAAA:BBBBBBBBBBBBBBBBBBBBBBBBBB

    BL00031A    <->A   (4,603):199
    7UP1_DROME 200     CVVCGDKSSGKHYGQFTCEGCKSFFKRSVRRNL
                       |||||||||||||||||||||||||||||||||
    7UP1_DROME 200     CVVCGDKSSGKHYGQFTCEGCKSFFKRSVRRNL

    BL00031B   A<->B   (0,10):1
    7UP1_DROME 234     YSCRGSRNCPIDQHHRNQCQYCRLKKCLKMGM
                       ||||||||||||||||||||||||||||||||
    7UP1_DROME 234     YSCRGSRNCPIDQHHRNQCQYCRLKKCLKMGM

    ------------------------------------------------------------------------------
    >PR00545 6/8 blocks: RETINOIC ACID RECEPTOR SIGNATURE
    Block    Frame    Location (aa)      Block E-value
    PR00545A    0        266-280                 51       **biased**
    PR00545C    0        335-355              0.066
    PR00545E    0        420-440                 36
    PR00545F    0        460-477                9.2
    PR00545G    0        481-500            1.1e-09
    PR00545H    0        508-527            0.00098
    Other reported alignments:

                             |---  116 amino acids---|
         PR00545 AAA::..BBBB::..CCCCC:::::.DDDD:::::...EEEEE::::FFFF:GGGG::HHHH
      7UP1_DROME <:::AAA::::::::::::CCCCC::::::::::::::EEEEE::::FFFF:GGGG::HHHH

    PR00545A    <->A   (120,271):265     PR00545C   A<->C   (39,55):54
    C41977     227     KREAVQEERQRGKER   C41977     288     SDPVTNICQAADKQLFTLVEW
                        |||||  |                                 |||  |   ||  |||
    7UP1_DROME 266     rREAVQrgRvpptQp   7UP1_DROME 335     imgidNICelAarlLFsaVEW

    PR00545E   C<->E   (63,80):64
    RRXG_HUMAN 347     FDRVLTELVSKMKDMQMDKSE
                         |   | | | |    |  |
    7UP1_DROME 420     hiRifqEqVeKlKalhvDsaE

    PR00545F   E<->F   (19,19):19           PR00545G   F<->G   (3,3):3
    RRXA_CHICK 391     PSEVESLREKVYATLEAY   C41977     433     KYPEQPGRFAKLLLRLPALR
                           ||| ||    || |                       || || || ||||||| ||
    7UP1_DROME 460     vthiESLqEKsqcaLEeY   7UP1_DROME 481     qYPnQPtRFgKLLLRLPsLR

    PR00545H   G<->H   (7,7):7
    C41977     460     EHLFFFKLIGDTPIDTFLME
                       | |||  | | ||| |
    7UP1_DROME 508     EqLFFvrLvGkTPIeTlird

    ------------------------------------------------------------------------------
    >PR00546 2/9 blocks: THYROID HORMONE RECEPTOR SIGNATURE
    Block    Frame    Location (aa)      Block E-value
    PR00546H    0        367-386                 34
    PR00546I    0        434-456                 11
    Other reported alignments:

                             |---  125 amino acids---|
         PR00546 AAA:::::BB:::::CCCDDDD:EEEE:FFFF:::..GGGG:HHHH:::::::::IIIII
      7UP1_DROME <:::::::::::::::::::::::::::::::::::::::::HHHH:::::::::IIIII

    PR00546H    <->H   (206,435):366
    THA1_HUMAN 244     CEDQIILLKGCCMEIMSLRA
                         ||  ||     |   | |
    7UP1_DROME 367     vtDQvaLLrlvwsElfvLnA

    PR00546I   H<->I   (45,45):47
    THA1_HUMAN 309     FNLDDTEVALLQAVLLMSTDRSG
                          |  |   | |  |  ||  |
    7UP1_DROME 434     lhvDsaEyscLkAivLftTDacG

    ------------------------------------------------------------------------------
    >PR00307 1/7 blocks: ADENOVIRUS FIBRE PROTEIN SIGNATURE
    Block    Frame    Location (aa)      Block E-value
    PR00307B    0          3-15                 1.2
    Other reported alignments:

                             |---  460 amino acids---|
         PR00307 AB:.........C................D:........................EF:::.G
      7UP1_DROME  B

    PR00307B    <->B   (18,43):2
    FIBP_ADECG 21      PKPSTQPPFFNDR
                         ||| | ||| |
    7UP1_DROME 3       asPSTaPGFFNPR

    ------------------------------------------------------------------------------
    >PR00678 1/10 blocks: PI3 KINASE P85 REGULATORY SUBUNIT SIGNATURE
    Block    Frame    Location (aa)      Block E-value
    PR00678D    0        416-434                1.6
    Other reported alignments:

                             |---  157 amino acids---|
         PR00678 AAA::::::BB::::CCCC::::::DDDEEEE:::::FFFGGGG::::HHHHIIIJJJJ
      7UP1_DROME <::::::::::::::::::::::::DDD

    PR00678D    <->D   (186,486):415
    RATP3KA    486     AFNDTIKIFEEQCHPQERY
                       || | | || ||
    7UP1_DROME 416     AFmDhIrIFqEQveklkal

    ------------------------------------------------------------------------------
    >BL01114 1/4 blocks: GPR1/FUN34/yaaH family proteins.
    Block    Frame    Location (aa)      Block E-value
    BL01114A    0        290-312                1.7       **biased**
    Other reported alignments:

                             |---   77 amino acids---|
         BL01114 AAAAAAA:::::.BBBBBBBBBBB:::::::..CCCCCCCCCCCCCDDDDDDDDDDDDDD
      7UP1_DROME AAAAAAA

    BL01114A    <->A   (4,85):289
    YD84_YEAST 83      QFANPVPLGLASFSLSCLVLSLI
                       | ||  | | | |       | |
    7UP1_DROME 290     QiANgdPmGiAGFnghsyLsSyI

    ------------------------------------------------------------------------------

    6 possible hits reported

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