# About Adding Sequences to Blocks

A protein sequence is added to a set of Blocks using the Blimps alignment algorithm based on the best single alignment of the sequence with each of the blocks. These best alignments must be in the correct order and non-overlapping, which is stricter than searching the sequence against the blocks.
After sequences are added to the blocks, they are re-weighted and re-calibrated.

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Page last modified August 2003