LOCUS       TAF6                    2737 bp    mRNA    linear   PRI 15-JAN-2003
DEFINITION  Homo sapiens TAF6 RNA polymerase II, TATA box binding protein
            (TBP)-associated factor, 80kDa (TAF6), transcript variant 1, mRNA.
ACCESSION   NM_005641
VERSION     NM_005641.2  GI:21536360
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2737)
  AUTHORS   Weinzierl,R.O., Ruppert,S., Dynlacht,B.D., Tanese,N. and Tjian,R.
  TITLE     Cloning and expression of Drosophila TAFII60 and human TAFII70
            reveal conserved interactions with other subunits of TFIID
  JOURNAL   EMBO J. 12 (13), 5303-5309 (1993)
  MEDLINE   94085406
PUBMED   8262073
REFERENCE   2  (bases 1 to 2737)
  AUTHORS   Hisatake,K., Ohta,T., Takada,R., Guermah,M., Horikoshi,M.,
            Nakatani,Y. and Roeder,R.G.
  TITLE     Evolutionary conservation of human
            TATA-binding-polypeptide-associated factors TAFII31 and TAFII80 and
            interactions of TAFII80 with other TAFs and with general
            transcription factors
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 92 (18), 8195-8199 (1995)
  MEDLINE   95396764
PUBMED   7667268
REFERENCE   3  (bases 1 to 2737)
  AUTHORS   Bell,B., Scheer,E. and Tora,L.
  TITLE     Identification of hTAF(II)80 delta links apoptotic signaling
            pathways to transcription factor TFIID function
  JOURNAL   Mol. Cell 8 (3), 591-600 (2001)
  MEDLINE   21468393
PUBMED   11583621
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from L25444.1 and AU143362.1.
            On Jun 21, 2002 this sequence version replaced gi:5032146.
            Summary: Initiation of transcription by RNA polymerase II requires
            the activities of more than 70 polypeptides. The protein that
            coordinates these activities is transcription factor IID (TFIID),
            which binds to the core promoter to position the polymerase
            properly, serves as the scaffold for assembly of the remainder of
            the transcription complex, and acts as a channel for regulatory
            signals. TFIID is composed of the TATA-binding protein (TBP) and a
            group of evolutionarily conserved proteins known as TBP-associated
            factors or TAFs. TAFs may participate in basal transcription, serve
            as coactivators, function in promoter recognition or modify general
            transcription factors (GTFs) to facilitate complex assembly and
            transcription initiation. This gene encodes one of the smaller
            subunits of TFIID that binds weakly to TBP but strongly to TAF1,
            the largest subunit of TFIID. Four isoforms have been identified
            but complete transcripts have been determined for only three
            isoforms. One of the isoforms has been shown to preclude binding of
            one of the other TFIID subunits, thereby reducing transcription and
            initiating signals that trigger apoptosis.
            Transcript Variant: This variant (1) encodes the longest isoform
            (alpha).
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..2737
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q22.1"
     gene 1..2737
                     /gene="TAF6"
                     /note="synonyms: TAF2E, TAFII70, TAFII80, TAFII85,
                     MGC:8964"
                     /db_xref="LocusID:6878"
                     /db_xref="MIM:602955"
     misc_feature 153..475
                     /gene="TAF6"
                     /note="Region: missing in transcript variants 2, 3 and 4"
     CDS 537..2570
                     /gene="TAF6"
                     /note="TAF6 RNA polymerase II, TATA box binding protein
                     (TBP)-associated factor, 80 kD; TATA box binding protein
                     (TBP)-associated factor, RNA polymerase II, E, 70/85kD;
                     transcription initiation factor TFIID 70 kD subunit"
                     /codon_start=1
                     /product="TBP-associated factor 6 isoform alpha"
                     /protein_id="NP_005632.1"
                     /db_xref="GI:5032147"
                     /db_xref="LocusID:6878"
                     /db_xref="MIM:602955"
                     /translation="MAEEKKLKLSNTVLPSESMKVVAESMGIAQIQEETCQLLTDEVS
                     YRIKEIAQDALKFMHMGKRQKLTTSDIDYALKLKNVEPLYGFHAQEFIPFRFASGGGR
                     ELYFYEEKEVDLSDIINTPLPRVPLDVCLKAHWLSIEGCQPAIPENPPPAPKEQQKAE
                     ATEPLKSAKPGQEEDGPLKGKGQGATTADGKGKEKKAPPLLEGAPLRLKPRSIHELSV
                     EQQLYYKEITEACVGSCEAKRAEALQSIATDPGLYQMLPRFSTFISEGVRVNVVQNNL
                     ALLIYLMRMVKALMDNPTLYLEKYVHELIPAVMTCIVSRQLCLRPDVDNHWALRDFAA
                     RLVAQICKHFSTTTNNIQSRITKTFTKSWVDEKTPWTTRYGSIAGLAELGHDVIKTLI
                     LPRLQQEGERIRSVLDGPVLSNIDRIGADHVQSLLLKHCAPVLAKLRPPPDNQDAYRA
                     EFGSLGPLLCSQVVKARAQAALQAQQVNRTTLTITQPRPTLTLSQAPQPGPRTPGLLK
                     VPGSIALPVQTLVSARAAAPPQPSPPPTKFIVMSSSSSAPSTQQVLSLSTSAPGSGST
                     TTSPVTTTVPSVQPIVKLVSTATTAPPSTAPSGPGSVQKYIVVSLPPTGEGKGGPTSH
                     PSPVPPPASSPSPLSGSALCGGKQEAGDSPPPAPGTPKANGSQPNSGSPQPAP"
     misc_feature 561..1760
                     /gene="TAF6"
                     /note="Region: COG5095, TAF6, Transcription initiation
                     factor TFIID, subunit TAF6 (also component of histone
                     acetyltransferase SAGA) [Transcription]"
                     /db_xref="CDD:COG5095"
     misc_feature 564..764
                     /gene="TAF6"
                     /note="TAF; Region: TATA box binding protein associated
                     factor (TAF). TAF proteins adopt a histone-like fold"
                     /db_xref="CDD:pfam02969"
     misc_feature 663..692
                     /gene="TAF6"
                     /note="Region: missing in transcript variant 4"
     misc_feature 1965..1994
                     /gene="TAF6"
                     /note="Region: missing in transcript variant 3"
     variation 2590
                     /gene="TAF6"
                     /allele="T"
                     /allele="C"
                     /db_xref="dbSNP:4134928"
     polyA_signal 2720..2725
                     /gene="TAF6"
                     /evidence=experimental
     polyA_site 2737
                     /gene="TAF6"
BASE COUNT      556 a    873 c    769 g    539 t
ORIGIN      
        1 gcggggccaa gatggcgccg agcgccgggt gagcagcgtc tcggctgccg ctagagtttt
       61 cctgctcccc gcgctcgggt ggcgggggcg ggtctgagtg gtaccccgga ggagaccctt
      121 tgaaggtccc ttgtggggac tggaaagagg acggttggtt gtgtgtctgt gctcgtgggg
      181 accccgtgtg tgtgcctgca ttggagagat gttgcaggag atggggtggg ctctctgaac
      241 ctcctttcgc gctgcccggg gatcttcgac ctgcttctct gctgggatct cgcttaagtt
      301 aacccttccc tgggacgcct tcctgccgcc tccactgatc tgaggagatc ctgtgactgt
      361 agcgtgtttt atgagccttt actggcagag ggtaccgccg ggtattgaag gattcgtagg
      421 agttcgccag ggaagtggga cacgaccccc tcttgtaaac ccggcgccag gcacagaggt
      481 ctccgtctct ccaccggggg cttcatcctt ccagggagga gaagagggac tccagaatgg
      541 ctgaggagaa gaagctgaag cttagcaaca ctgtgctgcc ctcggagtcc atgaaggtgg
      601 tggctgaatc catgggcatc gcccagattc aggaggagac ctgccagctg ctaacggatg
      661 aggtcagcta ccgcatcaaa gagatcgcac aggatgcctt gaagttcatg cacatgggga
      721 agcggcagaa gctcaccacc agtgacattg actacgcctt gaagctaaag aatgtcgagc
      781 cactctatgg cttccacgcc caggagttca ttcctttccg cttcgcctct ggtgggggcc
      841 gggagcttta cttctatgag gagaaggagg ttgatctgag cgacatcatc aatacccctc
      901 tgccccgggt gcccctggac gtctgcctca aagctcattg gctgagcatc gagggctgcc
      961 agccagctat ccccgagaac ccgcccccag ctcccaaaga gcaacagaag gctgaagcca
     1021 cagaacccct gaagtcagcc aagccaggcc aggaggaaga cggacccctg aagggcaaag
     1081 gtcaaggggc caccacagcc gacggcaaag ggaaagagaa gaaggcgccg cccttgctgg
     1141 agggggcccc cttgcgactg aagccccgga gcatccacga gttgtctgtg gagcagcagc
     1201 tctactacaa ggagatcacc gaggcctgcg tgggctcctg cgaggccaag agggcggaag
     1261 ccctgcaaag cattgccacg gaccctggac tgtatcagat gctgccacgg ttcagtacct
     1321 ttatctcgga gggggtccgt gtgaacgtgg ttcagaacaa cctggcccta ctcatctacc
     1381 tgatgcgtat ggtgaaagcg ctgatggaca accccacgct ctatctagaa aaatacgtcc
     1441 atgagctgat tccagctgtg atgacctgca tcgtgagcag acagttgtgc ctgcgaccag
     1501 atgtggacaa tcactgggca ctccgagact ttgctgcccg cctggtggcc cagatctgca
     1561 agcattttag cacaaccact aacaacatcc agtcccggat caccaagacc ttcaccaaga
     1621 gctgggtgga cgagaagacg ccctggacga ctcgttatgg ctccatcgca ggcttggctg
     1681 agctgggaca cgatgttatc aagactctga ttctgccccg gctgcagcag gaaggggagc
     1741 ggatccgcag tgtgctggac ggccctgtgc tgagcaacat tgaccggatt ggagcagacc
     1801 atgtgcagag cctcctgctg aaacactgtg ctcctgttct ggcaaagctg cgcccaccgc
     1861 ctgacaatca ggacgcctat cgggcagaat tcgggtccct tgggcccctc ctctgctccc
     1921 aggtggtcaa ggctcgggcc caggctgctc tgcaggctca gcaggtcaac aggaccactc
     1981 tgaccatcac gcagccccgg cccacgctga ccctctcgca ggccccacag cctggccctc
     2041 gcacccctgg cttgctgaag gttcctggct ccatcgcact tcctgtccag acactggtgt
     2101 ctgcacgagc ggctgcccca ccacagcctt cccctcctcc aaccaagttt attgtaatgt
     2161 catcgtcctc cagcgcccca tccacccagc aggtcctgtc cctcagcacc tcggcccccg
     2221 gctcaggttc caccaccact tcgcccgtca ccaccaccgt ccccagcgtg cagcccatcg
     2281 tcaagttggt ctccaccgcc accaccgcac cccccagcac tgctccctct ggtcctggga
     2341 gtgtccagaa gtacatcgtg gtctcacttc ccccaacagg ggagggcaaa ggaggcccca
     2401 cctcccatcc ttctccagtt cctcccccgg catcgtcccc gtccccactc agcggcagtg
     2461 ccctttgtgg ggggaagcag gaggctgggg acagtccccc tccagctcca gggactccaa
     2521 aagccaatgg ctcccagccc aactccggct cccctcagcc tgctccgtga tgctccacct
     2581 gccagccccc ggattcccac acatgcagac atgtacacac gtgcacgtac acacatgcat
     2641 gctcgctaag cggaaggaag ttgtagattg cttccttcat gtcactttct ttttagatat
     2701 tgtacagcca gtttctcaga ataaaagttt ggtttgt
//
