LOCUS       HSCKBG                  4200 bp    DNA     linear   PRI 24-APR-1993
DEFINITION  Human gene for creatine kinase B (EC 2.7.3.2).
ACCESSION   X15334
VERSION     X15334.1  GI:29962
KEYWORDS    creatine kinase; creatine kinase B.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4200)
  AUTHORS   Mariman,E.C., Schepens,J.T. and Wieringa,B.
  TITLE     Complete nucleotide sequence of the human creatine kinase B gene
  JOURNAL   Nucleic Acids Res. 17 (15), 6385 (1989)
  MEDLINE   89366665
PUBMED   2771648
REFERENCE   2  (bases 1 to 4200)
  AUTHORS   Mariman,E. and Wieringa,B.
  TITLE     Expression of the gene encoding human brain creatine kinase depends
            on sequences immediately following the transcription start point
  JOURNAL   Gene 102 (2), 205-212 (1991)
  MEDLINE   91340154
PUBMED   1840537
REFERENCE   3  (bases 1 to 4200)
  AUTHORS   Mariman,E.C.M.
  TITLE     Direct Submission
  JOURNAL   Submitted (23-MAY-1989) Mariman E.C.M., University of Nijmegen,
            Dept of Human Genetics, Geert Grooteplein Z18, 6525 GA Nijmegen,
            Netherlands
COMMENT     The sequence overlaps with that reported by Mariman et. al. in
            Genomics 1:126-137(1987)J03036 and by Daouk et. al. in J. Biol.
            Chem. 263:2442-2446(1988)J03531.
            Data kindly reviewed (13-NOV-1989) by Mariman E.C.M.
FEATURES             Location/Qualifiers
     source          1..4200
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /map="chromosome 14q32.3"
                     /clone="CK3-1"
                     /tissue_type="brain"
                     /clone_lib="EMBL3"
     CAAT_signal 724..728
     TATA_signal 742..749
     CAAT_signal 754..758
     mRNA join(808..875,1136..1340,1464..1618,1691..1823,2208..2379,
                     3050..3173,3331..3520,3600..4075)
     exon 808..875
                     /number=1
     intron 876..1135
                     /number=1
     exon 1136..1340
                     /number=2
     CDS join(1148..1340,1464..1618,1691..1823,2208..2379,
                     3050..3173,3331..3520,3600..3778)
                     /EC_number="2.7.3.2"
                     /codon_start=1
                     /product="creatine kinase B"
                     /protein_id="CAA33389.1"
                     /db_xref="GI:29963"
                     /db_xref="SWISS-PROT:P12277"
                     /translation="MPFSNSHNALKLRFPAEDEFPDLSAHNNHMAKVLTPELYAELRA
                     KSTPSGFTLDDVIQTGVDNPGHPYIMTVGCVAGDEESYEVFKDLFDPIIEDRHGGYKP
                     SDEHKTDLNPDNLQGGDDLDPNYVLSSRVRTGRSIRGFCLPPHCSRGERRAIEKLAVE
                     ALSSLDGDLAGRYYALKSMTEAEQQQLIDDHFLFDKPVSPLLLASGMARDWPDARGIW
                     HNDNKTFLVWVNEEDHLRVISMQKGGNMKEVFTRFCTGLTQIETLFKSKDYEFMWNPH
                     LGYILTCPSNLGTGLRAGVHIKLPNLGKHEKFSEVLKRLRLQKRGTGGVDTAAVGGVF
                     DVSNADRLGFSEVELVQMVVDGVKLLIEMEQRLEQGQAIDDLMPAQK"
     intron 1341..1463
                     /number=2
     exon 1464..1618
                     /number=3
     intron 1619..1690
                     /number=3
     exon 1691..1823
                     /number=4
     intron 1824..2207
                     /number=4
     exon 2208..2379
                     /number=5
     intron 2380..3049
                     /number=5
     exon 3050..3173
                     /number=6
     intron 3174..3330
                     /number=6
     exon 3331..3520
                     /number=7
     intron 3521..3599
                     /number=7
     exon 3600..4075
                     /number=8
     polyA_signal 3952..3957
BASE COUNT      586 a   1443 c   1477 g    694 t
ORIGIN      
        1 gatcagtttt tttttttaat cgcacttatg cttattgttt attagcgttt cctcccatct
       61 ttgcctgaag tctccgggga ctgcctttgg gggtcgggta aacttgtccc ctgcgaagag
      121 ggcccagggt tggggtctgg aaactccgag gctgcacttg ccagcggcct cttaaggcca
      181 cagcgtcccc gtggtttctg gctcgcagcc ccccgagacc caggacttgt ccaaggtcag
      241 ggcaccgcgg gtgcccccgg gctgggccgc agcagactgc gcttcccgcg cgccttcgct
      301 ttgcaccagg atcgcccagg aaatgcctgc gggcaccttg aggaaggtcg gcggctccgg
      361 gccagctcgc actggccggg gtggggcggg ggccgtacct gctgcggaag ccccgaaagc
      421 tttcgcccgg cccctcgccg ccgccgcggg ggctggctgg actaggcggg caggctcgag
      481 gatgcggatg aacccaagcg tcctcgagtg cccggaggct ctccgcctca gtttcccgcc
      541 cagaggcaag ggcgtgcgag gggatccaga tatccaagga cctgaggttt cggcctcgag
      601 gtcttgggcg ggggactggg caggctgcgc ggggtcccag cgaggggaca gctcgggtgg
      661 gcggccaggg tgttgggggc tgcgggcggc ggacaaagcg gcggcaccac cccgcggcgc
      721 gggccaatgg aatgaatggg ctataaatag ccgccaatgg gcggcccgcg ttgtgcccct
      781 taagagccgc gggagcgcgg agcggccgct gttcgcctgc gtcgctccgg gagctgccga
      841 cggacggagc gcccccgccc ccgcccggcc gcccggtgag tgggcccggg ggccgggggc
      901 gtccgcgccc gggctagggg cgctgcgagc aaagggggcg cgtcgcctgg agcgcgcgcc
      961 ggaccggccg ggggtccccg gcgatgatgg cgctccccgc gcgcgctgcg gaccccgctg
     1021 accttggccg cgtcccgggg ggcgccgggg ggcccggcgg cgggggcctg agtggtacgc
     1081 gggagcccgg gaaccccggc gtgccggtcc cctctgaccc cgcgtctccc cgcagcccgc
     1141 cgccgccatg cccttctcca acagccacaa cgcactgaag ctgcgcttcc cggccgagga
     1201 cgagttcccc gacctgagcg cccacaacaa ccacatggcc aaggtgctga cccccgagct
     1261 gtacgcggag ctgcgcgcca agagcacgcc gagcggcttc acgctggacg acgtcatcca
     1321 gacaggcgtg gacaacccgg gtacgcgacc cctcggggcc ggggtcccgg ccccccctcc
     1381 ccccgcgcag ccgcagggtc ctcagcagcg cgctcgggcc cggcagtgac gtcactgtcc
     1441 ccgtcccgcg ccccctcccc caggccaccc gtacatcatg accgtgggct gcgtggcggg
     1501 cgacgaggag tcctacgaag tgttcaagga tctcttcgac cccatcatcg aggaccggca
     1561 cggcggctac aagcccagcg atgagcacaa gaccgacctc aaccccgaca acctgcaggt
     1621 gcggggctgc gggcgggccg ggcgggcggg gccggggtct tcgggcgctc actcccgtct
     1681 cgcctcccag ggcggcgacg acctggaccc caactacgtg ctgagctcgc gggtgcgcac
     1741 gggccgcagc atccgtggct tctgcctccc cccgcactgc agccgcgggg agcgccgagc
     1801 catcgagaag ctcgcggtgg aaggtagggg ccgggcgggc cgaggggcgg cggcggccgc
     1861 gtccccctcc cggcgcggtc cccgcccgct tttgtttacg tcgcccggga gcggcagccg
     1921 ccgtcgcgct cttatctgcg cgcgcccggg ttcagtttcc cggacccacc gagggacgga
     1981 ggcccagccc ccgcgcccac agcggcctgg ggcccaggga gggcgggtcc tggcgcgggg
     2041 tcaccgcctg ggaccgtcgc ccgggccgtg aggactggac gcccgcagat ccgggcgggt
     2101 ggggccctct gacgtccccc gaggtggggc acgggggcgg gcgggtccgc gctgcgggct
     2161 ggaggggcgg gcgcgggagc ccagcgtcct gagcgcaccc ctcgcagccc tgtccagcct
     2221 ggacggcgac ctggcgggcc gatactacgc gctcaagagc atgacggagg cggagcagca
     2281 gcagctcatc gacgaccact tcctcttcga caagcccgtg tcgcccctgc tgctggcctc
     2341 gggcatggcc cgcgactggc ccgacgcccg cggtatctgg tgcgtgtccc tctgcgccct
     2401 ctcgcggcgt cctccctccc cgctacctcc gctttccctc tcgcccccct cgcgggggtg
     2461 gggcccctcg cggcgaggag gaggaggagg aggagggagg ggccggccgc gctccgggtc
     2521 tgggttccgt gccgcgcctc ctcctgcgcc ggtgaccttg gccgagcagg tgcgttaagg
     2581 gactgggccc cggcccgtgg gggctcagga ctcagcaaca cctccccacc ccgagacgtg
     2641 aggtgggggc ggggctctct ggcgcctctc cccgacggcc ctgggagctg gagctctttg
     2701 ttttcttttc tcactcctcc gccgctggga ttctaccagg ggctggtgac gccaaagctt
     2761 ctccaggggc agggctccta cccccactgt ggggggcggg tcgggctgtc ctggcggtcc
     2821 ctggccccgc cccacctcgg gccacagcgc atgatggcag ctggggttct cctgctgtga
     2881 ggcgtcccgg ttcccccgcc cgccccgtgt tggcgggtgg agtcttggca gcagcctcca
     2941 ctcctgggca tggcagggag cagcacctca gggacttggg aagttccttt ggtctggggg
     3001 cggcctgggg cttttttctg ggtatgccct gagaccagcc ctcccgcagg cacaatgaca
     3061 ataagacctt cctggtgtgg gtcaacgagg aggaccacct gcgggtcatc tccatgcaga
     3121 aggggggcaa catgaaggag gtgttcaccc gcttctgcac cggcctcacc caggtgccag
     3181 ggacggggca ggcccagacc ccagggcccc agcagggatg tgggtgcccc agcatcagtc
     3241 cccccggggg atttccggca ctggggagtc tcagggcctg taggggtttc aggcaggcct
     3301 tctccctcat accctcttct ccgtctgcag attgaaactc tcttcaagtc taaggactat
     3361 gagttcatgt ggaaccctca cctgggctac atcctcacct gcccatccaa cctgggcacc
     3421 gggctgcggg caggtgtgca tatcaagctg cccaacctgg gcaagcatga gaagttctcg
     3481 gaggtgctta agcggctgcg acttcagaag cgaggcacag gtgagcaggg caggtgctgc
     3541 ggcttcccgt ggcctttggg cagccctgtt tcctccgccc tgacttgctg tctccccagg
     3601 cggtgtggac acggctgcgg tgggcggggt cttcgacgtc tccaacgctg accgcctggg
     3661 cttctcagag gtggagctgg tgcagatggt ggtggacgga gtgaagctgc tcatcgagat
     3721 ggaacagcgg ctggagcagg gccaggccat cgacgacctc atgcctgccc agaaatgaag
     3781 cccggcccac acccgacacc agccctgctg cttcctaact tattgcctgg gcagtgccca
     3841 ccatgcaccc ctgatgttcg ccgtctggcg agcccttagc cttgctgtag agacttccgt
     3901 cacccttggt agagtttatt tttttgatgg ctaagatact gctgatgctg aaataaacta
     3961 gggttttggc ctgcctgcgt ctgagtggtg cctctccttt cccagggggg agggggaagg
     4021 gcagcagcca ggccccagga gtcttgagtc ctgggcctgc tgtgggcctc gccttctgtg
     4081 agatgggaca agagccagga ggtggccact ctgttctgcc tgccctacct agtccatggg
     4141 ccccttccct cgtgtctatc gggctgtgca ggcaggaaca tgggagagag cgagggagga
//
