format-version: 1.2
date: 21:06:2009 22:43
auto-generated-by: OBO-Edit 2.000-beta56
default-namespace: DC-CL

[Term]
id: CARO:0000013
name: cell
namespace: CARO
xref: CARO:0000013

[Term]
id: CARO:0000043
name: portion of tissue
namespace: CARO
xref: CARO:0000043

[Term]
id: CL:0000048
name: multi fate stem cell
namespace: CL
xref: CL:0000048
is_a: CARO:0000013 ! cell

[Term]
id: CL:0000738
name: leukocyte
namespace: CL
xref: CL:0000738
is_a: CARO:0000013 ! cell

[Term]
id: DC_CL:0000001
name: CD11c-low plasmacytoid dendritic cell
def: "CD11c-low plasmacytoid dendritic cell is_a leukocyte that has_low_plasma_membrane_amount_relative_to_leukocyte CD11c, has_plasma_membrane_part CD45R and GR1 and lacks_plasma_membrane_part CD11b, CD3, CD34, CD56, and CD19." [AMM:amm]
comment: Immunological Reviews 2007 219: 118-142; Annual Review of Immunology 2005 23: 275-306
xref: CL:0000784
intersection_of: CL:0000738 ! leukocyte
intersection_of: has_low_plasma_membrane_amount_relative_to_leukocyte PRO:000001013 ! CD11c
intersection_of: has_plasma_membrane_part DC_CL:0000100 ! GR1
intersection_of: has_plasma_membrane_part PRO:000001014 ! CD45R
intersection_of: lacks_plasma_membrane_part PRO:000001002 ! CD19
intersection_of: lacks_plasma_membrane_part PRO:000001003 ! CD34
intersection_of: lacks_plasma_membrane_part PRO:000001012 ! CD11b
intersection_of: lacks_plasma_membrane_part PRO:000001024 ! CD56
intersection_of: lacks_plasma_membrane_part PRO:000001027 ! CD3
relationship: has_disposition DC_CL:0000127 ! to secrete type I interferon
relationship: has_function DC_CL:0000133 ! T cell antigen presentation activity
relationship: has_function DC_CL:0000134 ! cytokine secretion activity
relationship: has_plasma_membrane_part DC_CL:0000065 ! CD281
relationship: has_plasma_membrane_part DC_CL:0000066 ! CD282
relationship: has_plasma_membrane_part DC_CL:0000069 ! CD286
relationship: has_plasma_membrane_part DC_CL:0000070 ! CD288
relationship: has_plasma_membrane_part DC_CL:0000071 ! CD289
relationship: has_plasma_membrane_part DC_CL:0000108 ! TLR5
relationship: has_plasma_membrane_part DC_CL:0000109 ! TLR7

[Term]
id: DC_CL:0000003
name: conventional dendritic cell
def: "conventional dendritic cell is_a leukocyte that has_high_plasma_membrane_amount_relative_to_leukocyte CD11c and lacks_plasma_membrane_part CD19, CD3, C34, and CD56." [AMM:amm]
comment: Immunological Reviews 2007 219: 118-142
intersection_of: CL:0000738 ! leukocyte
intersection_of: has_high_plasma_membrane_amount_relative_to_leukocyte PRO:000001013 ! CD11c
intersection_of: lacks_plasma_membrane_part PRO:000001002 ! CD19
intersection_of: lacks_plasma_membrane_part PRO:000001003 ! CD34
intersection_of: lacks_plasma_membrane_part PRO:000001024 ! CD56
intersection_of: lacks_plasma_membrane_part PRO:000001027 ! CD3

[Term]
id: DC_CL:0000004
name: CD11c-negative plasmacytoid dendritic cell
def: "CD11c-negative plasmacytoid dendritic cell is_a leukocyte that lacks_plasma_membrane_part CD11c, CD19, CD3, CD34, and CD56 and has_plasma_membrane_part CD123, CD303, CD45RA, and ILT7." [AMM:amm]
comment: Immunological Reviews 2007 219: 118-142; Annual Review of Immunology 2005 23: 275-306
xref: CL:0000784
intersection_of: CL:0000738 ! leukocyte
intersection_of: has_plasma_membrane_part DC_CL:0000101 ! ILT7
intersection_of: has_plasma_membrane_part PRO:000001015 ! CD45RA
intersection_of: has_plasma_membrane_part PRO:000001292 ! CD303
intersection_of: has_plasma_membrane_part PRO:000001865 ! CD123
intersection_of: lacks_plasma_membrane_part PRO:000001002 ! CD19
intersection_of: lacks_plasma_membrane_part PRO:000001003 ! CD34
intersection_of: lacks_plasma_membrane_part PRO:000001013 ! CD11c
intersection_of: lacks_plasma_membrane_part PRO:000001024 ! CD56
intersection_of: lacks_plasma_membrane_part PRO:000001027 ! CD3
relationship: has_disposition DC_CL:0000127 ! to secrete type I interferon
relationship: has_function DC_CL:0000133 ! T cell antigen presentation activity
relationship: has_function DC_CL:0000134 ! cytokine secretion activity
relationship: has_plasma_membrane_part DC_CL:0000065 ! CD281
relationship: has_plasma_membrane_part DC_CL:0000069 ! CD286
relationship: has_plasma_membrane_part DC_CL:0000071 ! CD289
relationship: has_plasma_membrane_part DC_CL:0000107 ! TLR10
relationship: has_plasma_membrane_part DC_CL:0000109 ! TLR7

[Term]
id: DC_CL:0000006
name: immature CD11c-low plasmacytoid dendritic cell
def: "immature CD11c-low plasmacytoid dendritic cell is_a CD11c-low plasmacytoid dendritic cell that has_low_plasma_membrane_amount_relative_to_leukocyte CD80 and CD86." [AMM:amm]
comment: Immunological Reviews 2007 219: 118-142; Annual Review of Immunology 2005 23: 275-306
intersection_of: DC_CL:0000001 ! CD11c-low plasmacytoid dendritic cell
intersection_of: has_low_plasma_membrane_amount_relative_to_leukocyte PRO:000001412 ! CD86
intersection_of: has_low_plasma_membrane_amount_relative_to_leukocyte PRO:000001438 ! CD80
relationship: arises_from DC_CL:0000041 ! common dendritic precursor
relationship: has_disposition DC_CL:0000125 ! to circulate in the blood
relationship: has_function DC_CL:0000135 ! antigen processing activity

[Term]
id: DC_CL:0000007
name: mature CD11c-low plasmacytoid dendritic cell
def: "mature CD11c-low plasmacytoid dendritic cell is_a CD11c-low plasmacytoid dendritic cell that has_plasma_membrane_part CD83 and has_high_plasma_membrane_amount_relative_to_leukocyte CD80, CD86, and MHCII." [AMM:amm]
comment: Immunological Reviews 2007 219: 118-142; Annual Review of Immunology 2005 23: 275-306
intersection_of: DC_CL:0000001 ! CD11c-low plasmacytoid dendritic cell
intersection_of: has_high_plasma_membrane_amount_relative_to_leukocyte DC_CL:0000103 ! MHCII
intersection_of: has_high_plasma_membrane_amount_relative_to_leukocyte PRO:000001412 ! CD86
intersection_of: has_high_plasma_membrane_amount_relative_to_leukocyte PRO:000001438 ! CD80
intersection_of: has_plasma_membrane_part PRO:000001310 ! CD83
relationship: transformation_of DC_CL:0000006 ! immature CD11c-low plasmacytoid dendritic cell

[Term]
id: DC_CL:0000008
name: immature CD11c-negative plasmacytoid dendritic cell
def: "immature CD11c-negative plasmacytoid dendritic cell is_a CD11c-negative plasmacytoid dendritic cell that lacks_plasma_membrane_part CD80 and has_low_plasma_membrane_amount_relative_to_leukocyte CD86 and MHCII." [AMM:amm]
comment: Immunological Reviews 2007 219: 118-142; Annual Review of Immunology 2005 23: 275-306
intersection_of: DC_CL:0000004 ! CD11c-negative plasmacytoid dendritic cell
intersection_of: has_low_plasma_membrane_amount_relative_to_leukocyte DC_CL:0000103 ! MHCII
intersection_of: has_low_plasma_membrane_amount_relative_to_leukocyte PRO:000001412 ! CD86
intersection_of: lacks_plasma_membrane_part PRO:000001438 ! CD80
relationship: arises_from DC_CL:1100000 ! CD71-positive common myeloid precursor OR CD7-negative lymphoid precursor OR CD7-positive lymphoid precursor
relationship: has_disposition DC_CL:0000125 ! to circulate in the blood
relationship: has_function DC_CL:0000135 ! antigen processing activity

[Term]
id: DC_CL:0000009
name: mature CD11c-negative plasmacytoid dendritic cell
def: "mature CD11c-negative plasmacytoid dendritic cell is_a CD11c-negative plasmacytoid dendritic cell that has_high_plasma_membrane_amount_relative_to_leukocyte CD80, CD86, and MHCII and has_plasma_membrane_part CD83," [AMM:amm]
comment: Immunological Reviews 2007 219: 118-142; Annual Review of Immunology 2005 23: 275-306
intersection_of: DC_CL:0000004 ! CD11c-negative plasmacytoid dendritic cell
intersection_of: has_high_plasma_membrane_amount_relative_to_leukocyte DC_CL:0000103 ! MHCII
intersection_of: has_high_plasma_membrane_amount_relative_to_leukocyte PRO:000001412 ! CD86
intersection_of: has_high_plasma_membrane_amount_relative_to_leukocyte PRO:000001438 ! CD80
intersection_of: has_plasma_membrane_part PRO:000001310 ! CD83
relationship: transformation_of DC_CL:0000008 ! immature CD11c-negative plasmacytoid dendritic cell

[Term]
id: DC_CL:0000010
name: immature CD8_alpha-negative CD11b-positive dendritic cell
def: "immature CD8_alpha-negative CD11b-positive dendritic cell is_a CD8_alpha-negative CD11b-positive dendritic cell that has_low_plasma_membrane_amount_relative_to_leukocyte CD80, CD86, and MHCII." [AMM:amm]
comment: Current Opinion In Immunology 2008 20: 61-67
intersection_of: DC_CL:0000012 ! CD8_alpha-negative CD11b-positive dendritic cell
intersection_of: has_low_plasma_membrane_amount_relative_to_leukocyte DC_CL:0000103 ! MHCII
intersection_of: has_low_plasma_membrane_amount_relative_to_leukocyte PRO:000001412 ! CD86
intersection_of: has_low_plasma_membrane_amount_relative_to_leukocyte PRO:000001438 ! CD80
relationship: arises_from DC_CL:0000041 ! common dendritic precursor
relationship: has_function DC_CL:0000135 ! antigen processing activity

[Term]
id: DC_CL:0000011
name: CD8_alpha-negative CD11b-negative dendritic cell
def: "CD8_alpha-negative CD11b-negative dendritic cell is_a conventional dendritic cell that lacks_plasma_membrane_part CD11b, CD4 and CD8_alpha and has_plasma_membrane_part CD205." [AMM:amm]
comment: Current Opinion In Immunology 2008 20: 61-67
intersection_of: DC_CL:0000003 ! conventional dendritic cell
intersection_of: has_plasma_membrane_part PRO:000001026 ! CD205
intersection_of: lacks_plasma_membrane_part DC_CL:0000090 ! CD8_alpha
intersection_of: lacks_plasma_membrane_part PRO:000001004 ! CD4
intersection_of: lacks_plasma_membrane_part PRO:000001012 ! CD11b
relationship: has_function DC_CL:0000133 ! T cell antigen presentation activity
relationship: has_function DC_CL:0000134 ! cytokine secretion activity
relationship: has_plasma_membrane_part DC_CL:0000065 ! CD281
relationship: has_plasma_membrane_part DC_CL:0000066 ! CD282
relationship: has_plasma_membrane_part DC_CL:0000067 ! CD283
relationship: has_plasma_membrane_part DC_CL:0000068 ! CD284
relationship: has_plasma_membrane_part DC_CL:0000069 ! CD286
relationship: has_plasma_membrane_part DC_CL:0000070 ! CD288
relationship: has_plasma_membrane_part DC_CL:0000071 ! CD289
relationship: has_plasma_membrane_part DC_CL:0000108 ! TLR5
relationship: has_plasma_membrane_part DC_CL:0000109 ! TLR7

[Term]
id: DC_CL:0000012
name: CD8_alpha-negative CD11b-positive dendritic cell
def: "CD8_alpha-negative CD11b-positive dendritic cell is_a conventional dendritic cell that has_plasma_membrane_part CD11b and CD4 and lacks_plasma_membrane_part CD205 and CD8_alpha." [AMM:amm]
comment: Current Opinion In Immunology 2008 20: 61-67
intersection_of: DC_CL:0000003 ! conventional dendritic cell
intersection_of: has_plasma_membrane_part PRO:000001004 ! CD4
intersection_of: has_plasma_membrane_part PRO:000001012 ! CD11b
intersection_of: lacks_plasma_membrane_part DC_CL:0000090 ! CD8_alpha
intersection_of: lacks_plasma_membrane_part PRO:000001026 ! CD205
relationship: has_disposition DC_CL:0000128 ! to secrete anti-inflammatory cytokines
relationship: has_function DC_CL:0000133 ! T cell antigen presentation activity
relationship: has_function DC_CL:0000134 ! cytokine secretion activity
relationship: has_plasma_membrane_part DC_CL:0000065 ! CD281
relationship: has_plasma_membrane_part DC_CL:0000066 ! CD282
relationship: has_plasma_membrane_part DC_CL:0000067 ! CD283
relationship: has_plasma_membrane_part DC_CL:0000068 ! CD284
relationship: has_plasma_membrane_part DC_CL:0000069 ! CD286
relationship: has_plasma_membrane_part DC_CL:0000070 ! CD288
relationship: has_plasma_membrane_part DC_CL:0000071 ! CD289
relationship: has_plasma_membrane_part DC_CL:0000108 ! TLR5
relationship: has_plasma_membrane_part DC_CL:0000109 ! TLR7

[Term]
id: DC_CL:0000013
name: CD8_alpha-positive CD11b-negative dendritic cell
def: "CD8_alpha-positive CD11b-negative dendritic cell is_a conventional dendritic cell that lacks_plasma_membrane_part CD11b and CD4 and has_plasma_membrane_part CD205 and CD8_alpha." [AMM:amm]
comment: Current Opinion In Immunology 2008 20: 61-67
intersection_of: DC_CL:0000003 ! conventional dendritic cell
intersection_of: has_plasma_membrane_part DC_CL:0000090 ! CD8_alpha
intersection_of: has_plasma_membrane_part PRO:000001026 ! CD205
intersection_of: lacks_plasma_membrane_part PRO:000001004 ! CD4
intersection_of: lacks_plasma_membrane_part PRO:000001012 ! CD11b
relationship: has_disposition DC_CL:0000124 ! to cross-present antigen to CD8 T cells
relationship: has_disposition DC_CL:0000129 ! to secrete inflammatory cytokines
relationship: has_function DC_CL:0000133 ! T cell antigen presentation activity
relationship: has_plasma_membrane_part DC_CL:0000065 ! CD281
relationship: has_plasma_membrane_part DC_CL:0000066 ! CD282
relationship: has_plasma_membrane_part DC_CL:0000067 ! CD283
relationship: has_plasma_membrane_part DC_CL:0000068 ! CD284
relationship: has_plasma_membrane_part DC_CL:0000069 ! CD286
relationship: has_plasma_membrane_part DC_CL:0000070 ! CD288
relationship: has_plasma_membrane_part DC_CL:0000071 ! CD289

[Term]
id: DC_CL:0000014
name: immature CD8_alpha-negative CD11b-negative dendritic cell
def: "immature CD8_alpha-negative CD11b-negative dendritic cell is_a CD8_alpha-negative CD11b-negative dendritic cell that has_low_plasma_membrane_amount_relative_to_leukocyte CD80, CD86, and MHCII." [AMM:amm]
comment: Current Opinion In Immunology 2008 20: 61-67
intersection_of: DC_CL:0000011 ! CD8_alpha-negative CD11b-negative dendritic cell
intersection_of: has_low_plasma_membrane_amount_relative_to_leukocyte DC_CL:0000103 ! MHCII
intersection_of: has_low_plasma_membrane_amount_relative_to_leukocyte PRO:000001412 ! CD86
intersection_of: has_low_plasma_membrane_amount_relative_to_leukocyte PRO:000001438 ! CD80
relationship: arises_from DC_CL:0000041 ! common dendritic precursor
relationship: has_function DC_CL:0000135 ! antigen processing activity

[Term]
id: DC_CL:0000015
name: mature CD8_alpha-negative CD11b-negative dendritic cell
def: "mature CD8_alpha-negative CD11b-negative dendritic cell is_a CD8_alpha-negative CD11b-negative dendritic cell that has_high_plasma_membrane_amount_relative_to_leukocyte CD80, CD86, and MHCII and has_plasma_membrane_part CD83." [AMM:amm]
comment: Current Opinion In Immunology 2008 20: 61-67
intersection_of: DC_CL:0000011 ! CD8_alpha-negative CD11b-negative dendritic cell
intersection_of: has_high_plasma_membrane_amount_relative_to_leukocyte DC_CL:0000103 ! MHCII
intersection_of: has_high_plasma_membrane_amount_relative_to_leukocyte PRO:000001412 ! CD86
intersection_of: has_high_plasma_membrane_amount_relative_to_leukocyte PRO:000001438 ! CD80
intersection_of: has_plasma_membrane_part PRO:000001310 ! CD83
relationship: has_disposition DC_CL:0000128 ! to secrete anti-inflammatory cytokines
relationship: transformation_of DC_CL:0000014 ! immature CD8_alpha-negative CD11b-negative dendritic cell

[Term]
id: DC_CL:0000016
name: mature CD8_alpha-negative CD11b-positive dendritic cell
def: "mature CD8_alpha-negative CD11b-positive dendritic cell is_a CD8_alpha-negative CD11b-positive dendritic cell that has_high_plasma_membrane_amount_relative_to_leukocyte CD80, CD86, and MHCII and has_plasma_membrane_part CD83." [AMM:amm]
comment: Current Opinion In Immunology 2008 20: 61-67
intersection_of: DC_CL:0000012 ! CD8_alpha-negative CD11b-positive dendritic cell
intersection_of: has_high_plasma_membrane_amount_relative_to_leukocyte DC_CL:0000103 ! MHCII
intersection_of: has_high_plasma_membrane_amount_relative_to_leukocyte PRO:000001412 ! CD86
intersection_of: has_high_plasma_membrane_amount_relative_to_leukocyte PRO:000001438 ! CD80
intersection_of: has_plasma_membrane_part PRO:000001310 ! CD83
relationship: transformation_of DC_CL:0000010 ! immature CD8_alpha-negative CD11b-positive dendritic cell

[Term]
id: DC_CL:0000017
name: immature CD8_alpha-positive CD11b-negative dendritic cell
def: "immature CD8_alpha-positive CD11b-negative dendritic cell is_a CD8_alpha-positive CD11b-negative dendritic cell that has_low_plasma_membrane_amount_relative_to_leukocyte CD80, CD86, and MHCII." [AMM:amm]
comment: Current Opinion In Immunology 2008 20: 61-67
intersection_of: DC_CL:0000013 ! CD8_alpha-positive CD11b-negative dendritic cell
intersection_of: has_low_plasma_membrane_amount_relative_to_leukocyte DC_CL:0000103 ! MHCII
intersection_of: has_low_plasma_membrane_amount_relative_to_leukocyte PRO:000001412 ! CD86
intersection_of: has_low_plasma_membrane_amount_relative_to_leukocyte PRO:000001438 ! CD80
relationship: arises_from DC_CL:0000041 ! common dendritic precursor

[Term]
id: DC_CL:0000018
name: mature CD8_alpha-positive CD11b-negative dendritic cell
def: "mature CD8_alpha-positive CD11b-negative dendritic cell is_a CD8_alpha-positive CD11b-negative dendritic cell that has_high_plasma_membrane_amount_relative_to_leukocyte CD80, CD86, and MHCII and has_plasma_membrane_part CD83." [AMM:amm]
comment: Current Opinion In Immunology 2008 20: 61-67
intersection_of: DC_CL:0000013 ! CD8_alpha-positive CD11b-negative dendritic cell
intersection_of: has_high_plasma_membrane_amount_relative_to_leukocyte DC_CL:0000103 ! MHCII
intersection_of: has_high_plasma_membrane_amount_relative_to_leukocyte PRO:000001412 ! CD86
intersection_of: has_high_plasma_membrane_amount_relative_to_leukocyte PRO:000001438 ! CD80
intersection_of: has_plasma_membrane_part PRO:000001310 ! CD83
relationship: transformation_of DC_CL:0000017 ! immature CD8_alpha-positive CD11b-negative dendritic cell

[Term]
id: DC_CL:0000019
name: dermal dendritic cell
def: "dermal dendritic cell is_a conventional dendritic cell that has_plasma_membrane_part CD11b and CD205 and lacks_plasma_membrane_part CD8_alpha." [AMM:amm]
comment: Current Opinion In Immunology 2008 20: 61-67
intersection_of: DC_CL:0000003 ! conventional dendritic cell
intersection_of: has_plasma_membrane_part PRO:000001012 ! CD11b
intersection_of: has_plasma_membrane_part PRO:000001026 ! CD205
intersection_of: lacks_plasma_membrane_part DC_CL:0000090 ! CD8_alpha
relationship: has_function DC_CL:0000133 ! T cell antigen presentation activity
relationship: has_function DC_CL:0000134 ! cytokine secretion activity
relationship: has_plasma_membrane_part DC_CL:0000065 ! CD281
relationship: has_plasma_membrane_part DC_CL:0000066 ! CD282
relationship: has_plasma_membrane_part DC_CL:0000067 ! CD283
relationship: has_plasma_membrane_part DC_CL:0000068 ! CD284
relationship: has_plasma_membrane_part DC_CL:0000070 ! CD288
relationship: has_plasma_membrane_part DC_CL:0000071 ! CD289
relationship: has_plasma_membrane_part DC_CL:0000108 ! TLR5

[Term]
id: DC_CL:0000020
name: interstitial dendritic cell
def: "interstitial dendritic cell is_a conventional dendritic cell that has_plasma_membrane_part CD11b, CD1a, CD206, CD209, and CD36." [AMM:amm]
comment: Immunological Reviews 2007 219: 118-142
intersection_of: DC_CL:0000003 ! conventional dendritic cell
intersection_of: has_plasma_membrane_part DC_CL:0000061 ! CD206
intersection_of: has_plasma_membrane_part PRO:000001012 ! CD11b
intersection_of: has_plasma_membrane_part PRO:000001300 ! CD209
intersection_of: has_plasma_membrane_part PRO:000001905 ! CD36
intersection_of: has_plasma_membrane_part PRO:000002025 ! CD1a
relationship: has_disposition DC_CL:0000126 ! to migrate to the lymph node
relationship: has_function DC_CL:0000133 ! T cell antigen presentation activity
relationship: has_function DC_CL:0000134 ! cytokine secretion activity
relationship: has_plasma_membrane_part DC_CL:0000065 ! CD281
relationship: has_plasma_membrane_part DC_CL:0000066 ! CD282
relationship: has_plasma_membrane_part DC_CL:0000067 ! CD283
relationship: has_plasma_membrane_part DC_CL:0000068 ! CD284
relationship: has_plasma_membrane_part DC_CL:0000069 ! CD286
relationship: has_plasma_membrane_part DC_CL:0000070 ! CD288
relationship: has_plasma_membrane_part DC_CL:0000107 ! TLR10

[Term]
id: DC_CL:0000021
name: Langerhans cell
def: "Langerhans cell is_a conventional dendritic cell that has_plasma_membrane_part CD207." [AMM:amm]
comment: Current Opinion In Immunology 2008 20: 61-67; Immunological Reviews 2007 219: 118-142
xref: CL:0000453
intersection_of: DC_CL:0000003 ! conventional dendritic cell
intersection_of: has_plasma_membrane_part PRO:000001293 ! CD207

[Term]
id: DC_CL:0000022
name: immature dermal dendritic cell
def: "immature dermal dendritic cell is_a dermal dendritic cell that has_low_plasma_membrane_amount_relative_to_leukocyte CD80, CD86, and MHCII." [AMM:amm]
comment: Current Opinion In Immunology 2008 20: 61-67
intersection_of: DC_CL:0000019 ! dermal dendritic cell
intersection_of: has_low_plasma_membrane_amount_relative_to_leukocyte DC_CL:0000103 ! MHCII
intersection_of: has_low_plasma_membrane_amount_relative_to_leukocyte PRO:000001412 ! CD86
intersection_of: has_low_plasma_membrane_amount_relative_to_leukocyte PRO:000001438 ! CD80
relationship: arises_from DC_CL:0000041 ! common dendritic precursor

[Term]
id: DC_CL:0000023
name: mature dermal dendritic cell
def: "mature dermal dendritic cell is_a dermal dendritic cell that has_high_plasma_membrane_amount_relative_to_leukocyte CD80, CD86, and MHCII and has_plasma_membrane_part CD83." [AMM:amm]
comment: Current Opinion In Immunology 2008 20: 61-67
intersection_of: DC_CL:0000019 ! dermal dendritic cell
intersection_of: has_high_plasma_membrane_amount_relative_to_leukocyte DC_CL:0000103 ! MHCII
intersection_of: has_high_plasma_membrane_amount_relative_to_leukocyte PRO:000001412 ! CD86
intersection_of: has_high_plasma_membrane_amount_relative_to_leukocyte PRO:000001438 ! CD80
intersection_of: has_plasma_membrane_part PRO:000001310 ! CD83
relationship: transformation_of DC_CL:0000022 ! immature dermal dendritic cell

[Term]
id: DC_CL:0000024
name: immature interstitial dendritic cell
def: "immature interstitial dendritic cell is_a interstitial dendritic cell that has_low_plasma_membrane_amount_relative_to_leukocyte CD80, CD86, and MHCII." [AMM:amm]
comment: Immunological Reviews 2007 219: 118-142
intersection_of: DC_CL:0000020 ! interstitial dendritic cell
intersection_of: has_low_plasma_membrane_amount_relative_to_leukocyte DC_CL:0000103 ! MHCII
intersection_of: has_low_plasma_membrane_amount_relative_to_leukocyte PRO:000001412 ! CD86
intersection_of: has_low_plasma_membrane_amount_relative_to_leukocyte PRO:000001438 ! CD80
relationship: arises_from DC_CL:1110000 ! CD7-negative lymphoid precursor OR granulocyte monocyte progenitor
relationship: has_function DC_CL:0000135 ! antigen processing activity
relationship: has_function DC_CL:0000136 ! transportation of antigen activity

[Term]
id: DC_CL:0000025
name: mature interstitial dendritic cell
def: "mature interstitial dendritic cell is_a interstitial dendritic cell that has_high_plasma_membrane_amount_relative_to_leukocyte CD80, CD86, and MHCII and has_plasma_membrane_part CD83." [AMM:amm]
comment: Immunological Reviews 2007 219: 118-142
intersection_of: DC_CL:0000020 ! interstitial dendritic cell
intersection_of: has_high_plasma_membrane_amount_relative_to_leukocyte DC_CL:0000103 ! MHCII
intersection_of: has_high_plasma_membrane_amount_relative_to_leukocyte PRO:000001412 ! CD86
intersection_of: has_high_plasma_membrane_amount_relative_to_leukocyte PRO:000001438 ! CD80
intersection_of: has_plasma_membrane_part PRO:000001310 ! CD83
relationship: transformation_of DC_CL:0000024 ! immature interstitial dendritic cell

[Term]
id: DC_CL:0000026
name: CD1a-positive Langerhans cell
def: "CD1a-positive Langerhans cell is_a Langerhans_cell that has_plasma_membrane_part CD1a and CD324." [AMM:amm]
comment: Immunological Reviews 2007 219: 118-142
intersection_of: DC_CL:0000021 ! Langerhans cell
intersection_of: has_plasma_membrane_part PRO:000001447 ! CD324
intersection_of: has_plasma_membrane_part PRO:000002025 ! CD1a
relationship: has_disposition DC_CL:0000126 ! to migrate to the lymph node
relationship: has_function DC_CL:0000133 ! T cell antigen presentation activity
relationship: has_function DC_CL:0000134 ! cytokine secretion activity
relationship: has_plasma_membrane_part DC_CL:0000065 ! CD281
relationship: has_plasma_membrane_part DC_CL:0000066 ! CD282
relationship: has_plasma_membrane_part DC_CL:0000068 ! CD284
relationship: has_plasma_membrane_part DC_CL:0000069 ! CD286
relationship: has_plasma_membrane_part DC_CL:0000107 ! TLR10
relationship: has_plasma_membrane_part DC_CL:0000109 ! TLR7

[Term]
id: DC_CL:0000027
name: CD8_alpha-low Langerhans cell
def: "CD8_alpha-low Langerhans cell is_a Langerhans cell that has_high_plasma_membrane_amount_relative_to_leukocyte CD205 and has_low_plasma_membrane_amount_relative_to_leukocyte CD8_alpha." [AMM:amm]
comment: Current Opinion In Immunology 2008 20: 61-67
intersection_of: DC_CL:0000021 ! Langerhans cell
intersection_of: has_high_plasma_membrane_amount_relative_to_leukocyte PRO:000001026 ! CD205
intersection_of: has_low_plasma_membrane_amount_relative_to_leukocyte DC_CL:0000090 ! CD8_alpha
relationship: has_disposition DC_CL:0000126 ! to migrate to the lymph node
relationship: has_function DC_CL:0000133 ! T cell antigen presentation activity
relationship: has_function DC_CL:0000134 ! cytokine secretion activity
relationship: has_plasma_membrane_part DC_CL:0000065 ! CD281
relationship: has_plasma_membrane_part DC_CL:0000066 ! CD282
relationship: has_plasma_membrane_part DC_CL:0000067 ! CD283
relationship: has_plasma_membrane_part DC_CL:0000068 ! CD284
relationship: has_plasma_membrane_part DC_CL:0000069 ! CD286
relationship: has_plasma_membrane_part DC_CL:0000070 ! CD288
relationship: has_plasma_membrane_part DC_CL:0000071 ! CD289
relationship: has_plasma_membrane_part DC_CL:0000107 ! TLR10
relationship: has_plasma_membrane_part DC_CL:0000108 ! TLR5

[Term]
id: DC_CL:0000028
name: immature CD1a-positive Langerhans cell
def: "immature CD1a-positive Langerhans cell is_a CD1a-positive Langerhans cell that has_low_plasma_membrane_amount_relative_to_leukocyte CD80, CD86, and MHCII." [AMM:amm]
comment: Immunological Reviews 2007 219: 118-142
intersection_of: DC_CL:0000026 ! CD1a-positive Langerhans cell
intersection_of: has_low_plasma_membrane_amount_relative_to_leukocyte DC_CL:0000103 ! MHCII
intersection_of: has_low_plasma_membrane_amount_relative_to_leukocyte PRO:000001412 ! CD86
intersection_of: has_low_plasma_membrane_amount_relative_to_leukocyte PRO:000001438 ! CD80
relationship: has_function DC_CL:0000135 ! antigen processing activity
relationship: has_function DC_CL:0000136 ! transportation of antigen activity

[Term]
id: DC_CL:0000029
name: mature CD1a-positive Langerhans cell
def: "mature CD1a-positive Langerhans cell is_a CD1a-positive Langerhans cell that has_high_plasma_membrane_amount_relative_to_leukocyte CD80, CD86, and MHCII and has_plasma_membrane_part CD83." [AMM:amm]
comment: Immunological Reviews 2007 219: 118-142
intersection_of: DC_CL:0000026 ! CD1a-positive Langerhans cell
intersection_of: has_high_plasma_membrane_amount_relative_to_leukocyte DC_CL:0000103 ! MHCII
intersection_of: has_high_plasma_membrane_amount_relative_to_leukocyte PRO:000001412 ! CD86
intersection_of: has_high_plasma_membrane_amount_relative_to_leukocyte PRO:000001438 ! CD80
intersection_of: has_plasma_membrane_part PRO:000001310 ! CD83
relationship: transformation_of DC_CL:0000028 ! immature CD1a-positive Langerhans cell

[Term]
id: DC_CL:0000030
name: immature CD8_alpha-low Langerhans cell
def: "immature CD8_alpha-low Langerhans cell is_a CD8_alpha-low Langerhans cell that has_low_plasma_membrane_amount_relative_to_leukocyte CD80, CD86, and MHCII." [AMM:amm]
comment: Current Opinion In Immunology 2008 20: 61-67
intersection_of: DC_CL:0000027 ! CD8_alpha-low Langerhans cell
intersection_of: has_low_plasma_membrane_amount_relative_to_leukocyte DC_CL:0000103 ! MHCII
intersection_of: has_low_plasma_membrane_amount_relative_to_leukocyte PRO:000001412 ! CD86
intersection_of: has_low_plasma_membrane_amount_relative_to_leukocyte PRO:000001438 ! CD80
relationship: arises_from DC_CL:1111000 ! CD115-positive monocyte OR common dendritic precursor

[Term]
id: DC_CL:0000031
name: mature CD8_alpha-low Langerhans cell
def: "mature CD8_alpha-low Langerhans cell is_a CD8_alpha-low Langerhans cell that has_high_plasma_membrane_amount_relative_to_leukocyte CD80, CD86, and MHCII and has_plasma_membrane_part CD83." [AMM:amm]
comment: Current Opinion In Immunology 2008 20: 61-67
intersection_of: DC_CL:0000027 ! CD8_alpha-low Langerhans cell
intersection_of: has_high_plasma_membrane_amount_relative_to_leukocyte DC_CL:0000103 ! MHCII
intersection_of: has_high_plasma_membrane_amount_relative_to_leukocyte PRO:000001412 ! CD86
intersection_of: has_high_plasma_membrane_amount_relative_to_leukocyte PRO:000001438 ! CD80
intersection_of: has_plasma_membrane_part PRO:000001310 ! CD83
relationship: transformation_of DC_CL:0000030 ! immature CD8_alpha-low Langerhans cell

[Term]
id: DC_CL:0000032
name: CD10-positive common lymphoid precursor
def: "CD10-positive common lymphoid precursor is_a multi fate stem cell that has_plasma_membrane_part CD10, CD45RA, and CD34 and lacks_plasma_membrane_part CD19, CD3, and CD4." [AMM:amm]
comment: Current Opinion In Immunology 2008 20: 61-67
intersection_of: CL:0000048 ! multi fate stem cell
intersection_of: has_plasma_membrane_part PRO:000001003 ! CD34
intersection_of: has_plasma_membrane_part PRO:000001015 ! CD45RA
intersection_of: has_plasma_membrane_part PRO:000001898 ! CD10
intersection_of: lacks_plasma_membrane_part PRO:000001002 ! CD19
intersection_of: lacks_plasma_membrane_part PRO:000001004 ! CD4
intersection_of: lacks_plasma_membrane_part PRO:000001027 ! CD3
relationship: arises_from DC_CL:0000035 ! CD133-positive hematopoietic stem cell

[Term]
id: DC_CL:0000033
name: CD115-positive monocyte
def: "CD115-positive monocyte is_a leukocyte that has_plasma_membrane_part CD115 and CD11b." [AMM:amm]
comment: Nature Immunology 2007 8: 1199-1201
intersection_of: CL:0000738 ! leukocyte
intersection_of: has_plasma_membrane_part PRO:000001012 ! CD11b
intersection_of: has_plasma_membrane_part PRO:000002062 ! CD115
relationship: arises_from DC_CL:0000034 ! CD117-positive common myeloid precursor
relationship: has_disposition DC_CL:0000125 ! to circulate in the blood

[Term]
id: DC_CL:0000034
name: CD117-positive common myeloid precursor
def: "CD117-positive common myeloid precursor is_a multi fate stem cell that has_plasma_membrane_part CD117 and CD34 and lacks_plasma_membrane_part CD2, CD217, CD3, CD4, CD45R, CD5, CD8, GR1, NK1.1, SCA1, and Ter-119." [AMM:amm]
comment: Nature Immunology 2007 8: 1199-1201
intersection_of: CL:0000048 ! multi fate stem cell
intersection_of: has_plasma_membrane_part PRO:000001003 ! CD34
intersection_of: has_plasma_membrane_part PRO:000002065 ! CD117
intersection_of: lacks_plasma_membrane_part DC_CL:0000089 ! CD8
intersection_of: lacks_plasma_membrane_part DC_CL:0000100 ! GR1
intersection_of: lacks_plasma_membrane_part DC_CL:0000104 ! NK1.1
intersection_of: lacks_plasma_membrane_part DC_CL:0000105 ! SCA1
intersection_of: lacks_plasma_membrane_part DC_CL:0000106 ! Ter-119
intersection_of: lacks_plasma_membrane_part PRO:000001004 ! CD4
intersection_of: lacks_plasma_membrane_part PRO:000001014 ! CD45R
intersection_of: lacks_plasma_membrane_part PRO:000001027 ! CD3
intersection_of: lacks_plasma_membrane_part PRO:000001083 ! CD2
intersection_of: lacks_plasma_membrane_part PRO:000001375 ! CD217
intersection_of: lacks_plasma_membrane_part PRO:000001839 ! CD5
relationship: arises_from DC_CL:0000043 ! SCA1-positive hematopoietic stem cell

[Term]
id: DC_CL:0000035
name: CD133-positive hematopoietic stem cell
def: "CD133-positive hematopoietic stem_cell is_a multi fate stem cell that has_plasma_membrane_part CD133 and CD34 and lacks_plasma_membrane_part CD11b, CD15, CD16, CD19, CD2, CD3, CD33, CD56, and CD71." [AMM:amm]
comment: Annual Review of Immunology 2006 24: 287-320
intersection_of: CL:0000048 ! multi fate stem cell
intersection_of: has_plasma_membrane_part PRO:000001003 ! CD34
intersection_of: has_plasma_membrane_part PRO:000001786 ! CD133
intersection_of: lacks_plasma_membrane_part PRO:000001002 ! CD19
intersection_of: lacks_plasma_membrane_part PRO:000001012 ! CD11b
intersection_of: lacks_plasma_membrane_part PRO:000001024 ! CD56
intersection_of: lacks_plasma_membrane_part PRO:000001027 ! CD3
intersection_of: lacks_plasma_membrane_part PRO:000001083 ! CD2
intersection_of: lacks_plasma_membrane_part PRO:000001456 ! CD15
intersection_of: lacks_plasma_membrane_part PRO:000001483 ! CD16
intersection_of: lacks_plasma_membrane_part PRO:000001892 ! CD33
intersection_of: lacks_plasma_membrane_part PRO:000001945 ! CD71

[Term]
id: DC_CL:0000036
name: CD217-positive common lymphoid precursor
def: "CD217-positive common lymphoid precursor is_a multi fate stem cell that has_plasma_membrane_part CD117, CD217, SCA1 and lacks_plasma_membrane_part CD2, CD3, CD4, CD45R, CD5, GR1, CD8, NK1.1, Ter-119." [AMM:amm]
comment: Nature Immunology 2007 8: 1199-1201
intersection_of: CL:0000048 ! multi fate stem cell
intersection_of: has_plasma_membrane_part PRO:000001375 ! CD217
intersection_of: has_plasma_membrane_part PRO:000002065 ! CD117
intersection_of: lacks_plasma_membrane_part DC_CL:0000089 ! CD8
intersection_of: lacks_plasma_membrane_part DC_CL:0000100 ! GR1
intersection_of: lacks_plasma_membrane_part DC_CL:0000104 ! NK1.1
intersection_of: lacks_plasma_membrane_part DC_CL:0000106 ! Ter-119
intersection_of: lacks_plasma_membrane_part PRO:000001004 ! CD4
intersection_of: lacks_plasma_membrane_part PRO:000001014 ! CD45R
intersection_of: lacks_plasma_membrane_part PRO:000001027 ! CD3
intersection_of: lacks_plasma_membrane_part PRO:000001083 ! CD2
intersection_of: lacks_plasma_membrane_part PRO:000001839 ! CD5
relationship: arises_from DC_CL:0000043 ! SCA1-positive hematopoietic stem cell

[Term]
id: DC_CL:0000038
name: CD71-positive common myeloid precursor
def: "CD71-positive common myeloid precursor is_a multi fate stem cell that has_plasma_membrane_part CD34, CD45RA, and CD71 and lacks_plasma_membrane_part CD10, CD19, CD3, CD4, and CD7." [AMM:amm]
comment: Annual Review of Immunology 2006 24: 287-320
intersection_of: CL:0000048 ! multi fate stem cell
intersection_of: has_plasma_membrane_part PRO:000001003 ! CD34
intersection_of: has_plasma_membrane_part PRO:000001015 ! CD45RA
intersection_of: has_plasma_membrane_part PRO:000001945 ! CD71
intersection_of: lacks_plasma_membrane_part PRO:000001002 ! CD19
intersection_of: lacks_plasma_membrane_part PRO:000001004 ! CD4
intersection_of: lacks_plasma_membrane_part PRO:000001027 ! CD3
intersection_of: lacks_plasma_membrane_part PRO:000001836 ! CD7
intersection_of: lacks_plasma_membrane_part PRO:000001898 ! CD10
relationship: arises_from DC_CL:0000035 ! CD133-positive hematopoietic stem cell

[Term]
id: DC_CL:0000039
name: CD7-negative lymphoid precursor
def: "CD7-negative lymphoid precursor is_a leukocyte that has_plasma_membrane_part CD34 and lacks_plasma_membrane_part CD19, CD3, CD4, CD45RA, and CD7." [AMM:amm]
comment: Annual Review of Immunology 2006 24: 287-320
intersection_of: CL:0000738 ! leukocyte
intersection_of: has_plasma_membrane_part PRO:000001003 ! CD34
intersection_of: lacks_plasma_membrane_part PRO:000001002 ! CD19
intersection_of: lacks_plasma_membrane_part PRO:000001004 ! CD4
intersection_of: lacks_plasma_membrane_part PRO:000001015 ! CD45RA
intersection_of: lacks_plasma_membrane_part PRO:000001027 ! CD3
intersection_of: lacks_plasma_membrane_part PRO:000001836 ! CD7
relationship: arises_from DC_CL:0000032 ! CD10-positive common lymphoid precursor

[Term]
id: DC_CL:0000040
name: CD7-positive lymphoid precursor
def: "CD7-positive lymphoid precursor is_a leukocyte that has_plasma_membrane_part CD34 and CD7 and lacks_plasma_membrane_part CD19, CD3, CD4, CD45RA." [AMM:amm]
comment: Annual Review of Immunology 2006 24: 287-320
intersection_of: CL:0000738 ! leukocyte
intersection_of: has_plasma_membrane_part PRO:000001003 ! CD34
intersection_of: has_plasma_membrane_part PRO:000001836 ! CD7
intersection_of: lacks_plasma_membrane_part PRO:000001002 ! CD19
intersection_of: lacks_plasma_membrane_part PRO:000001004 ! CD4
intersection_of: lacks_plasma_membrane_part PRO:000001015 ! CD45RA
intersection_of: lacks_plasma_membrane_part PRO:000001027 ! CD3
relationship: arises_from DC_CL:0000032 ! CD10-positive common lymphoid precursor

[Term]
id: DC_CL:0000041
name: common dendritic precursor
def: "common dendritic precursor is_a leukocyte that has_plasma_membrane_part CD117, CD135, and M-CSFR." [AMM:amm]
comment: Annual Review of Immunology 2006 24: 287-320
intersection_of: CL:0000738 ! leukocyte
intersection_of: has_plasma_membrane_part DC_CL:0000102 ! M-CSFR
intersection_of: has_plasma_membrane_part PRO:000002001 ! CD135
intersection_of: has_plasma_membrane_part PRO:000002065 ! CD117
relationship: arises_from DC_CL:1111100 ! CD117-positive common myeloid precursor OR CD217-positive common lymphoid precursor

[Term]
id: DC_CL:0000042
name: granulocyte monocyte progenitor
def: "granulocyte monocyte progenitor is_a leukocyte that has_plasma_membrane_part CD123, CD34, and CD45RA and lacks_plasma_membrane_part CD19 and CD3." [AMM:amm]
comment: Annual Review of Immunology 2006 24: 287-320
intersection_of: CL:0000738 ! leukocyte
intersection_of: has_plasma_membrane_part PRO:000001003 ! CD34
intersection_of: has_plasma_membrane_part PRO:000001015 ! CD45RA
intersection_of: has_plasma_membrane_part PRO:000001865 ! CD123
intersection_of: lacks_plasma_membrane_part PRO:000001027 ! CD3
relationship: arises_from DC_CL:0000038 ! CD71-positive common myeloid precursor

[Term]
id: DC_CL:0000043
name: SCA1-positive hematopoietic stem cell
def: "SCA1-positive hematopoietic stem cell is_a multi fate stem cell that has_plasma_membrane_part CD117 and SCA1 and lacks_plasma_membrane_part CD2, CD3, C34, CD4, CD45R, CD5, CD8, CD90,GR1, NK1.1, Ter-119." [AMM:amm]
comment: Nature Immunology 2007 8: 1199-1201
intersection_of: CL:0000048 ! multi fate stem cell
intersection_of: has_plasma_membrane_part DC_CL:0000105 ! SCA1
intersection_of: has_plasma_membrane_part PRO:000002065 ! CD117
intersection_of: lacks_plasma_membrane_part DC_CL:0000089 ! CD8
intersection_of: lacks_plasma_membrane_part DC_CL:0000100 ! GR1
intersection_of: lacks_plasma_membrane_part DC_CL:0000104 ! NK1.1
intersection_of: lacks_plasma_membrane_part DC_CL:0000106 ! Ter-119
intersection_of: lacks_plasma_membrane_part PRO:000001003 ! CD34
intersection_of: lacks_plasma_membrane_part PRO:000001004 ! CD4
intersection_of: lacks_plasma_membrane_part PRO:000001014 ! CD45R
intersection_of: lacks_plasma_membrane_part PRO:000001027 ! CD3
intersection_of: lacks_plasma_membrane_part PRO:000001083 ! CD2
intersection_of: lacks_plasma_membrane_part PRO:000001839 ! CD5
intersection_of: lacks_plasma_membrane_part PRO:000001843 ! CD90

[Term]
id: DC_CL:0000046
name: CD2
is_obsolete: true

[Term]
id: DC_CL:0000047
name: CD10
is_obsolete: true

[Term]
id: DC_CL:0000048
name: CD115
synonym: "CSF1R" EXACT []
is_obsolete: true

[Term]
id: DC_CL:0000049
name: CD117
synonym: "cKit" EXACT []
is_obsolete: true

[Term]
id: DC_CL:0000052
name: CD123
is_obsolete: true

[Term]
id: DC_CL:0000053
name: CD133
is_obsolete: true

[Term]
id: DC_CL:0000054
name: CD135
synonym: "FLT3" EXACT []
is_obsolete: true

[Term]
id: DC_CL:0000055
name: CD14
is_a: FMA:63887 ! biological macromolecule

[Term]
id: DC_CL:0000056
name: CD15
is_obsolete: true

[Term]
id: DC_CL:0000057
name: CD16
synonym: "FCGR3" EXACT []
is_obsolete: true

[Term]
id: DC_CL:0000059
name: CD1a
is_obsolete: true

[Term]
id: DC_CL:0000061
name: CD206
synonym: "Mannose Receptor Protein" EXACT []
is_a: FMA:63887 ! biological macromolecule

[Term]
id: DC_CL:0000062
name: CD207
synonym: "langerin" EXACT []
is_obsolete: true

[Term]
id: DC_CL:0000063
name: CD209
synonym: "DC-SIGN" EXACT []
is_obsolete: true

[Term]
id: DC_CL:0000064
name: CD217
synonym: "IL7R alpha" EXACT []
is_obsolete: true

[Term]
id: DC_CL:0000065
name: CD281
synonym: "TLR1" EXACT []
is_a: FMA:63887 ! biological macromolecule

[Term]
id: DC_CL:0000066
name: CD282
synonym: "TLR2" EXACT []
is_a: FMA:63887 ! biological macromolecule

[Term]
id: DC_CL:0000067
name: CD283
synonym: "TLR3" EXACT []
is_a: FMA:63887 ! biological macromolecule

[Term]
id: DC_CL:0000068
name: CD284
synonym: "TLR4" EXACT []
is_a: FMA:63887 ! biological macromolecule

[Term]
id: DC_CL:0000069
name: CD286
synonym: "TLR6" EXACT []
is_a: FMA:63887 ! biological macromolecule

[Term]
id: DC_CL:0000070
name: CD288
synonym: "TLR8" EXACT []
is_a: FMA:63887 ! biological macromolecule

[Term]
id: DC_CL:0000071
name: CD289
synonym: "TLR9" EXACT []
is_a: FMA:63887 ! biological macromolecule

[Term]
id: DC_CL:0000072
name: CD3
is_obsolete: true

[Term]
id: DC_CL:0000073
name: CD303
synonym: "BDCA_2" EXACT []
is_obsolete: true

[Term]
id: DC_CL:0000074
name: CD31
is_a: FMA:63887 ! biological macromolecule

[Term]
id: DC_CL:0000075
name: CD32
is_a: FMA:63887 ! biological macromolecule

[Term]
id: DC_CL:0000076
name: CD324
synonym: "E-cadherin" EXACT []
is_obsolete: true

[Term]
id: DC_CL:0000077
name: CD33
is_obsolete: true

[Term]
id: DC_CL:0000079
name: CD36
is_obsolete: true

[Term]
id: DC_CL:0000081
name: CD43
is_a: FMA:63887 ! biological macromolecule

[Term]
id: DC_CL:0000082
name: CD45
is_a: FMA:63887 ! biological macromolecule

[Term]
id: DC_CL:0000083
name: CD5
is_obsolete: true

[Term]
id: DC_CL:0000085
name: CD62L
is_a: FMA:63887 ! biological macromolecule

[Term]
id: DC_CL:0000086
name: CD64
is_a: FMA:63887 ! biological macromolecule

[Term]
id: DC_CL:0000087
name: CD7
is_obsolete: true

[Term]
id: DC_CL:0000088
name: CD71
is_obsolete: true

[Term]
id: DC_CL:0000089
name: CD8
is_a: FMA:63887 ! biological macromolecule

[Term]
id: DC_CL:0000090
name: CD8_alpha
is_a: DC_CL:0000089 ! CD8

[Term]
id: DC_CL:0000091
name: CD8_beta
is_a: DC_CL:0000089 ! CD8

[Term]
id: DC_CL:0000092
name: CD45R
comment: Synonym B220 used to refer to mouse isoform.
synonym: "B220" NARROW []
is_obsolete: true

[Term]
id: DC_CL:0000094
name: CD80
is_obsolete: true

[Term]
id: DC_CL:0000095
name: CD83
is_obsolete: true

[Term]
id: DC_CL:0000096
name: CD86
is_obsolete: true

[Term]
id: DC_CL:0000097
name: CD90
synonym: "THy1.1" EXACT []
is_obsolete: true

[Term]
id: DC_CL:0000098
name: CXCR2
is_a: FMA:63887 ! biological macromolecule

[Term]
id: DC_CL:0000099
name: CXCR4
is_a: FMA:63887 ! biological macromolecule

[Term]
id: DC_CL:0000100
name: GR1
is_a: FMA:63887 ! biological macromolecule

[Term]
id: DC_CL:0000101
name: ILT7
is_a: FMA:63887 ! biological macromolecule

[Term]
id: DC_CL:0000102
name: M-CSFR
is_a: FMA:63887 ! biological macromolecule

[Term]
id: DC_CL:0000103
name: MHCII
is_a: FMA:63887 ! biological macromolecule

[Term]
id: DC_CL:0000104
name: NK1.1
is_a: FMA:63887 ! biological macromolecule

[Term]
id: DC_CL:0000105
name: SCA1
is_a: FMA:63887 ! biological macromolecule

[Term]
id: DC_CL:0000106
name: Ter-119
is_a: FMA:63887 ! biological macromolecule

[Term]
id: DC_CL:0000107
name: TLR10
is_a: FMA:63887 ! biological macromolecule

[Term]
id: DC_CL:0000108
name: TLR5
is_a: FMA:63887 ! biological macromolecule

[Term]
id: DC_CL:0000109
name: TLR7
is_a: FMA:63887 ! biological macromolecule

[Term]
id: DC_CL:0000118
name: mouse lamina propria
comment: There is currently no corresponding term in the mouse anatomy ontology.
is_a: UBERON:0000030 ! lamina propria
relationship: is_location_of DC_CL:0000012 ! CD8_alpha-negative CD11b-positive dendritic cell
relationship: is_location_of DC_CL:0000013 ! CD8_alpha-positive CD11b-negative dendritic cell

[Term]
id: DC_CL:0000124
name: to cross-present antigen to CD8 T cells
namespace: IO
is_a: DC_CL:1000000 ! cell disposition

[Term]
id: DC_CL:0000125
name: to circulate in the blood
namespace: IO
is_a: DC_CL:1000000 ! cell disposition

[Term]
id: DC_CL:0000126
name: to migrate to the lymph node
namespace: IO
is_a: DC_CL:1000000 ! cell disposition

[Term]
id: DC_CL:0000127
name: to secrete type I interferon
namespace: IO
is_a: DC_CL:1000000 ! cell disposition

[Term]
id: DC_CL:0000128
name: to secrete anti-inflammatory cytokines
namespace: IO
is_a: DC_CL:1000000 ! cell disposition

[Term]
id: DC_CL:0000129
name: to secrete inflammatory cytokines
namespace: IO
is_a: DC_CL:1000000 ! cell disposition

[Term]
id: DC_CL:0000133
name: T cell antigen presentation activity
namespace: IO
is_a: DC_CL:0100000 ! cell function

[Term]
id: DC_CL:0000134
name: cytokine secretion activity
namespace: IO
is_a: DC_CL:0100000 ! cell function

[Term]
id: DC_CL:0000135
name: antigen processing activity
namespace: IO
is_a: DC_CL:0100000 ! cell function

[Term]
id: DC_CL:0000136
name: transportation of antigen activity
namespace: IO
is_a: DC_CL:0100000 ! cell function

[Term]
id: DC_CL:0100000
name: cell function

[Term]
id: DC_CL:1000000
name: cell disposition

[Term]
id: DC_CL:1100000
name: CD71-positive common myeloid precursor OR CD7-negative lymphoid precursor OR CD7-positive lymphoid precursor
namespace: DC_CL
is_a: CARO:0000013 ! cell
union_of: DC_CL:0000038 ! CD71-positive common myeloid precursor
union_of: DC_CL:0000039 ! CD7-negative lymphoid precursor
union_of: DC_CL:0000040 ! CD7-positive lymphoid precursor

[Term]
id: DC_CL:1110000
name: CD7-negative lymphoid precursor OR granulocyte monocyte progenitor
is_a: CARO:0000013 ! cell
union_of: DC_CL:0000039 ! CD7-negative lymphoid precursor
union_of: DC_CL:0000042 ! granulocyte monocyte progenitor

[Term]
id: DC_CL:1111000
name: CD115-positive monocyte OR common dendritic precursor
is_a: CARO:0000013 ! cell
union_of: DC_CL:0000033 ! CD115-positive monocyte
union_of: DC_CL:0000041 ! common dendritic precursor

[Term]
id: DC_CL:1111100
name: CD117-positive common myeloid precursor OR CD217-positive common lymphoid precursor
is_a: CARO:0000013 ! cell
union_of: DC_CL:0000034 ! CD117-positive common myeloid precursor
union_of: DC_CL:0000036 ! CD217-positive common lymphoid precursor

[Term]
id: FMA:5034
name: human lymph node
namespace: FMA
comment: Defined in the FMA as 'lymph node'.
xref: FMA:5034
is_a: UBERON:0000029 ! lymph node
relationship: is_location_of DC_CL:0000004 ! CD11c-negative plasmacytoid dendritic cell
relationship: is_location_of DC_CL:0000020 ! interstitial dendritic cell
relationship: is_location_of DC_CL:0000026 ! CD1a-positive Langerhans cell

[Term]
id: FMA:63887
name: biological macromolecule
namespace: FMA
comment: We use the FMA term because there is no corresponding term in CARO. The FMA term may refer only to human entities. We include as sub-types, types observed in mouse or human or both. In addition, we included types of proteins as well as types of protein complexes. Protein types will be defined in PRO; protein complexes will be defined in GO CC. Where PRO types have already been defined, we include the PRO ID.
xref: FMA:63887

[Term]
id: FMA:67498
name: organ
namespace: FMA
comment: We use the FMA term because there is no corresponding term in CARO. The FMA term may refer only to human entities. We include as sub-types, types observed in mouse or human or both.
xref: FMA:67498

[Term]
id: FMA:70323
name: human dermis
namespace: FMA
comment: Defined in the FMA as 'dermis'.
xref: FMA:70323
is_a: UBERON:FMA_70323-MA_0000152-MIAA_0000153-XAO_0000217-ZFA_0001119 ! dermis
relationship: is_location_of DC_CL:0000020 ! interstitial dendritic cell

[Term]
id: FMA:70596
name: human epidermis
namespace: FMA
comment: Defined in the FMA using the term 'epidermis'.
xref: FMA:70596
is_a: UBERON:FBbt_00004993-FBbt_00005401-FMA_70596-MA_0000153-MIAA_0000154-WBbt_0005733-XAO_0000028-ZFA_0000105 ! epidermis
relationship: is_location_of DC_CL:0000026 ! CD1a-positive Langerhans cell

[Term]
id: FMA:7196
name: human spleen
namespace: FMA
comment: Defined in the FMA as 'spleen'.
xref: FMA:7196
is_a: UBERON:FMA_7196-MA_0000141-MIAA_0000085-XAO_0000328-ZFA_0000436 ! spleen
relationship: is_location_of DC_CL:0000003 ! conventional dendritic cell
relationship: is_location_of DC_CL:0000004 ! CD11c-negative plasmacytoid dendritic cell

[Term]
id: FMA:9607
name: human thymus
namespace: FMA
comment: Defined in the Foundational Model of Anatomy as 'thymus'.
xref: FMA:9607
is_a: UBERON:FMA_9607-MA_0000142-MIAA_0000080-XAO_0000163-ZFA_0001078 ! thymus
relationship: is_location_of DC_CL:0000001 ! CD11c-low plasmacytoid dendritic cell
relationship: is_location_of DC_CL:0000020 ! interstitial dendritic cell

[Term]
id: FMA:9608
name: human bone marrow
namespace: FMA
comment: Defined in the FMA as 'bone marrow'.
xref: FMA:9608
is_a: UBERON:FMA_9608-MA_0000134-MIAA_0000084-XAO_0000123-ZFA_0000669 ! bone marrow
relationship: is_location_of DC_CL:0000032 ! CD10-positive common lymphoid precursor
relationship: is_location_of DC_CL:0000033 ! CD115-positive monocyte
relationship: is_location_of DC_CL:0000035 ! CD133-positive hematopoietic stem cell
relationship: is_location_of DC_CL:0000038 ! CD71-positive common myeloid precursor
relationship: is_location_of DC_CL:0000039 ! CD7-negative lymphoid precursor
relationship: is_location_of DC_CL:0000040 ! CD7-positive lymphoid precursor
relationship: is_location_of DC_CL:0000042 ! granulocyte monocyte progenitor

[Term]
id: MA:0000134
name: mouse bone marrow
namespace: MA
comment: Defined in the mouse anatomy ontology as 'bone marrow'.
xref: MA:0000134
is_a: UBERON:FMA_9608-MA_0000134-MIAA_0000084-XAO_0000123-ZFA_0000669 ! bone marrow
relationship: is_location_of DC_CL:0000034 ! CD117-positive common myeloid precursor
relationship: is_location_of DC_CL:0000036 ! CD217-positive common lymphoid precursor
relationship: is_location_of DC_CL:0000041 ! common dendritic precursor
relationship: is_location_of DC_CL:0000043 ! SCA1-positive hematopoietic stem cell

[Term]
id: MA:0000137
name: mouse Peyer's patch
namespace: MA
comment: Defined in the mouse anatomy ontology as 'peyer's patch'.
xref: MA:0000137
is_a: UBERON:FMA_15054-MA_0000137 ! aggregated lymphoid follicle of small intestine
relationship: is_location_of DC_CL:0000011 ! CD8_alpha-negative CD11b-negative dendritic cell
relationship: is_location_of DC_CL:0000012 ! CD8_alpha-negative CD11b-positive dendritic cell
relationship: is_location_of DC_CL:0000013 ! CD8_alpha-positive CD11b-negative dendritic cell

[Term]
id: MA:0000139
name: mouse lymph node
namespace: MA
comment: Defined in the mouse anatomy ontology as 'lymph node'.
xref: MA:0000139
is_a: UBERON:0000029 ! lymph node
relationship: is_location_of DC_CL:0000001 ! CD11c-low plasmacytoid dendritic cell
relationship: is_location_of DC_CL:0000012 ! CD8_alpha-negative CD11b-positive dendritic cell
relationship: is_location_of DC_CL:0000013 ! CD8_alpha-positive CD11b-negative dendritic cell
relationship: is_location_of DC_CL:0000019 ! dermal dendritic cell
relationship: is_location_of DC_CL:0000027 ! CD8_alpha-low Langerhans cell

[Term]
id: MA:0000141
name: mouse spleen
namespace: MA
comment: Defined in the mouse anatomy ontology as 'spleen'.
xref: MA:0000141
is_a: UBERON:FMA_7196-MA_0000141-MIAA_0000085-XAO_0000328-ZFA_0000436 ! spleen
relationship: is_location_of DC_CL:0000001 ! CD11c-low plasmacytoid dendritic cell
relationship: is_location_of DC_CL:0000012 ! CD8_alpha-negative CD11b-positive dendritic cell
relationship: is_location_of DC_CL:0000013 ! CD8_alpha-positive CD11b-negative dendritic cell

[Term]
id: MA:0000142
name: mouse thymus
namespace: MA
comment: Defined in the mouse anatomy ontology as 'thymus'.
xref: MA:0000142
is_a: UBERON:FMA_9607-MA_0000142-MIAA_0000080-XAO_0000163-ZFA_0001078 ! thymus
relationship: is_location_of DC_CL:0000011 ! CD8_alpha-negative CD11b-negative dendritic cell
relationship: is_location_of DC_CL:0000012 ! CD8_alpha-negative CD11b-positive dendritic cell
relationship: is_location_of DC_CL:0000013 ! CD8_alpha-positive CD11b-negative dendritic cell

[Term]
id: MA:0000152
name: mouse dermis
namespace: MA
comment: Defined in the mouse anatomy ontology as 'dermis'.
xref: MA:0000152
is_a: UBERON:FMA_70323-MA_0000152-MIAA_0000153-XAO_0000217-ZFA_0001119 ! dermis
relationship: is_location_of DC_CL:0000019 ! dermal dendritic cell

[Term]
id: MA:0000153
name: mouse epidermis
namespace: MA
comment: Defined in the mouse anatomy ontology as 'epidermis'.
xref: MA:0000153
is_a: UBERON:FBbt_00004993-FBbt_00005401-FMA_70596-MA_0000153-MIAA_0000154-WBbt_0005733-XAO_0000028-ZFA_0000105 ! epidermis
relationship: is_location_of DC_CL:0000027 ! CD8_alpha-low Langerhans cell

[Term]
id: PRO:000001002
name: CD19
namespace: PRO
xref: PRO:000001002
is_a: FMA:63887 ! biological macromolecule

[Term]
id: PRO:000001003
name: CD34
namespace: PRO
xref: PRO:000001003
is_a: FMA:63887 ! biological macromolecule

[Term]
id: PRO:000001004
name: CD4
namespace: PRO
xref: PRO:000001004
is_a: FMA:63887 ! biological macromolecule

[Term]
id: PRO:000001012
name: CD11b
namespace: PRO
xref: PRO:000001012
is_a: FMA:63887 ! biological macromolecule

[Term]
id: PRO:000001013
name: CD11c
namespace: PRO
xref: PRO:000001013
is_a: FMA:63887 ! biological macromolecule

[Term]
id: PRO:000001014
name: CD45R
namespace: PRO
comment: Synonym B220 used to refer to mouse isoform.
synonym: "B220" NARROW []
is_a: DC_CL:0000082 ! CD45

[Term]
id: PRO:000001015
name: CD45RA
namespace: PRO
xref: PRO:000001015
is_a: DC_CL:0000082 ! CD45

[Term]
id: PRO:000001024
name: CD56
namespace: PRO
xref: PRO:000001024
is_a: FMA:63887 ! biological macromolecule

[Term]
id: PRO:000001026
name: CD205
namespace: PRO
synonym: "DEC 205" EXACT []
synonym: "Ly75" EXACT []
xref: PRO:000001026
is_a: FMA:63887 ! biological macromolecule

[Term]
id: PRO:000001027
name: CD3
namespace: PRO
is_a: FMA:63887 ! biological macromolecule

[Term]
id: PRO:000001083
name: CD2
namespace: PRO
is_a: FMA:63887 ! biological macromolecule

[Term]
id: PRO:000001292
name: CD303
namespace: PRO
synonym: "BDCA_2" EXACT []
is_a: FMA:63887 ! biological macromolecule

[Term]
id: PRO:000001293
name: CD207
namespace: PRO
synonym: "langerin" EXACT []
is_a: FMA:63887 ! biological macromolecule

[Term]
id: PRO:000001300
name: CD209
namespace: PRO
synonym: "DC-SIGN" EXACT []
is_a: FMA:63887 ! biological macromolecule

[Term]
id: PRO:000001310
name: CD83
namespace: PRO
is_a: FMA:63887 ! biological macromolecule

[Term]
id: PRO:000001375
name: CD217
namespace: PRO
synonym: "IL7R alpha" EXACT []
is_a: FMA:63887 ! biological macromolecule

[Term]
id: PRO:000001412
name: CD86
namespace: PRO
is_a: FMA:63887 ! biological macromolecule

[Term]
id: PRO:000001438
name: CD80
namespace: PRO
is_a: FMA:63887 ! biological macromolecule

[Term]
id: PRO:000001447
name: CD324
namespace: PRO
synonym: "E-cadherin" EXACT []
is_a: FMA:63887 ! biological macromolecule

[Term]
id: PRO:000001456
name: CD15
namespace: PRO
is_a: FMA:63887 ! biological macromolecule

[Term]
id: PRO:000001483
name: CD16
namespace: PRO
synonym: "FCGR3" EXACT []
is_a: FMA:63887 ! biological macromolecule

[Term]
id: PRO:000001786
name: CD133
namespace: PRO
is_a: FMA:63887 ! biological macromolecule

[Term]
id: PRO:000001836
name: CD7
namespace: PRO
is_a: FMA:63887 ! biological macromolecule

[Term]
id: PRO:000001839
name: CD5
namespace: PRO
is_a: FMA:63887 ! biological macromolecule

[Term]
id: PRO:000001843
name: CD90
namespace: PRO
synonym: "THy1.1" EXACT []
is_a: FMA:63887 ! biological macromolecule

[Term]
id: PRO:000001865
name: CD123
namespace: PRO
is_a: FMA:63887 ! biological macromolecule

[Term]
id: PRO:000001892
name: CD33
namespace: PRO
is_a: FMA:63887 ! biological macromolecule

[Term]
id: PRO:000001898
name: CD10
namespace: PRO
is_a: FMA:63887 ! biological macromolecule

[Term]
id: PRO:000001905
name: CD36
namespace: PRO
is_a: FMA:63887 ! biological macromolecule

[Term]
id: PRO:000001945
name: CD71
namespace: PRO
is_a: FMA:63887 ! biological macromolecule

[Term]
id: PRO:000002001
name: CD135
namespace: PRO
synonym: "FLT3" EXACT []
is_a: FMA:63887 ! biological macromolecule

[Term]
id: PRO:000002025
name: CD1a
namespace: PRO
is_a: FMA:63887 ! biological macromolecule

[Term]
id: PRO:000002062
name: CD115
namespace: PRO
synonym: "CSF1R" EXACT []
is_a: FMA:63887 ! biological macromolecule

[Term]
id: PRO:000002065
name: CD117
namespace: PRO
synonym: "cKit" EXACT []
is_a: FMA:63887 ! biological macromolecule

[Term]
id: UBERON:0000029
name: lymph node
namespace: UBERON
xref: UBERON:0000029
is_a: FMA:67498 ! organ

[Term]
id: UBERON:0000030
name: lamina propria
namespace: UBERON
xref: UBERON:0000030
is_a: CARO:0000043 ! portion of tissue

[Term]
id: UBERON:FBbt_00004993-FBbt_00005401-FMA_70596-MA_0000153-MIAA_0000154-WBbt_0005733-XAO_0000028-ZFA_0000105
name: epidermis
namespace: UBERON
xref: FBbt:00004993
xref: FBbt:00005401
xref: FMA:70596
xref: MA:0000153
xref: MIAA:0000154
xref: UBERON:FBbt_00004993-FBbt_00005401-FMA_70596-MA_0000153-MIAA_0000154-WBbt_0005733-XAO_0000028-ZFA_0000105
xref: WBbt:0005733
xref: XAO:0000028
xref: ZFA:0000105
is_a: CARO:0000043 ! portion of tissue

[Term]
id: UBERON:FMA_15054-MA_0000137
name: aggregated lymphoid follicle of small intestine
namespace: UBERON
xref: FMA:15054
xref: MA:0000137
xref: UBERON:FMA_15054-MA_0000137
is_a: CARO:0000043 ! portion of tissue

[Term]
id: UBERON:FMA_70323-MA_0000152-MIAA_0000153-XAO_0000217-ZFA_0001119
name: dermis
namespace: UBERON
xref: FMA:70323
xref: MA:0000152
xref: MIAA:0000153
xref: UBERON:FMA_70323-MA_0000152-MIAA_0000153-XAO_0000217-ZFA_0001119
xref: XAO:0000217
xref: ZFA:0001119
is_a: CARO:0000043 ! portion of tissue

[Term]
id: UBERON:FMA_7196-MA_0000141-MIAA_0000085-XAO_0000328-ZFA_0000436
name: spleen
namespace: UBERON
xref: FMA:7196
xref: MA:0000141
xref: MIAA:0000085
xref: UBERON:FMA_7196-MA_0000141-MIAA_0000085-XAO_0000328-ZFA_0000436
xref: XAO:0000328
xref: ZFA:0000436
is_a: FMA:67498 ! organ

[Term]
id: UBERON:FMA_9607-MA_0000142-MIAA_0000080-XAO_0000163-ZFA_0001078
name: thymus
namespace: UBERON
xref: FMA:9607
xref: MA:0000142
xref: MIAA:0000080
xref: UBERON:FMA_9607-MA_0000142-MIAA_0000080-XAO_0000163-ZFA_0001078
xref: XAO:0000163
xref: ZFA:0001078
is_a: FMA:67498 ! organ

[Term]
id: UBERON:FMA_9608-MA_0000134-MIAA_0000084-XAO_0000123-ZFA_0000669
name: bone marrow
namespace: UBERON
xref: FMA:9608
xref: MA:0000134
xref: MIAA:0000084
xref: UBERON:FMA_9608-MA_0000134-MIAA_0000084-XAO_0000123-ZFA_0000669
xref: XAO:0000123
xref: ZFA:0000669
is_a: CARO:0000043 ! portion of tissue

[Typedef]
id: arises_from
name: arises_from

[Typedef]
id: has_disposition
name: has_disposition

[Typedef]
id: has_function
name: has_function

[Typedef]
id: has_high_plasma_membrane_amount_relative_to_leukocyte
name: has_high_plasma_membrane_amount_relative_to_leukocyte

[Typedef]
id: has_low_plasma_membrane_amount_relative_to_leukocyte
name: has_low_plasma_membrane_amount_relative_to_leukocyte

[Typedef]
id: has_plasma_membrane_part
name: has_plasma_membrane_part

[Typedef]
id: is_location_of
name: is_location_of

[Typedef]
id: lacks_plasma_membrane_part
name: lacks_plasma_membrane_part

[Typedef]
id: transformation_of
name: transformation_of
